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immunohistochemistry

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  • آنتی بادیهای ایمونوهیستوشیمی

    آنتی ­بادی Cytokeratin 10 (SP99)

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    Name: Cytokeratin 10 Antibody Clone SP99

    Description and applications: Cytokeratin 10 is a type I cytokeratin, expressed by suprabasal cells of stratified and cornified epithelia. Its defects are implicated in bullous congenital ichthyosiform rythroderma, epidermolytic hyperkeratosis and diffuse non-epidermolytic palomoplantar keratoderma.

    Composition: Anti-human Cytokeratin 10 rabbit monoclonal antibody purified from serum and prepared in 10mM PBS, pH 7.4, with 0.2% BSA and 0.09% sodium azide,

    Immunogen: Synthetic peptide corresponding to the C-terminus of human keratin 10.

  • آنتی بادیهای ایمونوهیستوشیمی

    آنتی ­بادی Cytokeratin 13 (EP69)

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    Name: Keratin 13 Monoclonal Antibody Clone EP69

    Description and aplications: The nomenclature coined in 1982 by Moll and Franke assigned ranges from 1 to 8 for cytokeratin type II (neutral or basic) and between 9 and 21 for type I (acidic). However and because of the high homology among the different molecules is common for a single monoclonal antibody to react with different types of keratins , for example keratin brand AE1 keratins 10, 14 , 15, 16 and 19. The 54 kD keratin 13 is the major acidic keratin that is assembled in vivo with type 4 and is expressed in the suprabasal cells of the multilayered keratinizing epithelium of mucous membranes, transitional epithelium, pseudostratified epithelium and myoepithelial cells. The monoclonal anti- keratin 13 antibody has been used as a marker for non-keratinized squamous epithelium and is expressed in various squamous metaplasias, but is down regulated in squamous dysplasia and squamous carcinoma. It is useful to identify epithelial derived tumors of the trachea, apocrine and eccrine sweat glands, salivary glands, stem cells of the endocervical glands, bladder, exocervix , tongue, esophagus, anus and basal layer of the epidermis.In addition, mutations in the gene sequence of keratin 13 have been implicated in genetic disease known as autosomal dominant white sponge nevus of the oral cavity.

    Composition: anti-Keratin 13 rabbit monoclonal antibody obtained from supernatant culture and prediluted in a tris buffered solution pH 7.4 containing 0.375mM sodium azide solution as bacteriostatic and bactericidal. The amount of the active antibody was not determined.

    Immunogen: Synthetic peptide corresponding to human keratin 13 residues.

     

  • Prolactin Antibody (Clone EP193)
    آنتی بادیهای ایمونوهیستوشیمی

    آنتی‌ بادی Prolactin (EP193)

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    Name: Prolactin Antibody clone EP193

    Description and applications: Prolactin is a peptide hormone secreted by the anterior pituitary that is necessary for the proliferation and differentiation of the mammary glands. Prolactin also acts in a cytokine-like manner and as an important regulator of the immune system. Prolactin has important cell cycle related functions as a growth, differentiating and antiapoptotic factor. Prolactin is secreted by lactotrophs in the anterior pituitary. Prolactin producing cells make up approximately 20 percent of the pituitary. Elevated counts of these cells have been observed in pregnant women, newborns and in multiparous women. An antibody to prolactin is useful for the identification of pituitary tumors.

    Composition: Anti-human Prolactin rabbit monoclonal antibody purified from serum and prepared in 10mM PBS, pH 7.4, with 0.2% BSA and 0.09% sodium azide

    Immunogen: A synthetic peptide corresponding to residues of human Prolactin protein

  • PSA
    آنتی بادیهای ایمونوهیستوشیمی

    آنتی ­بادی Prostate-specific antigen (PSA) (ER-PR8)

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    Name: PSA antibody Clone ER-PR8

    Description and applications: PSA is an antigen present in prostatic tissue and in the majority of prostatic carcinomas. This antibody recognizes primary and metastatic prostatic neoplasms and rarely in tumors of nonprostatic origin. These include breast and a minority of salivary gland tumors. The antigen is a 33-34 kD glycoprotein that is restricted to epithelial cells of the prostate. Because of the high specificity of PSA for prostate glandular epithelium, the antibody is useful to identify prostatic carcinomas of the prostate and their frequent infiltration of the surrounding organs (eg .: rectum and urinary bladder). Rectal adenocarcinomas, urothelial carcinoma or adenocarcinoma of the urinary bladder did not express PSA. The loss of immunoreactivity for PSA which can occur in poorly differentiated neoplasms cannot completely exclude the diagnosis of prostate cancer with a negative PSA. Another important use is for differential diagnosis and determine the origin of the primary tumor with metastases of unknown origin, especially lymph node and bone. PSA can be used together with the Prostein, which has at least the same sensitivity and is slightly more specific tha PSA.

    Composition: anti-human PSA mouse monoclonal antibody purified from supernatant diluted in tris bffered saline, pH 7.3-7.7, with protein base, and preserved with sodium azide.

  • آنتی بادیهای ایمونوهیستوشیمی

    آنتی ­بادی Prostatic Acid Phosphatase (PASE/4LJ)

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    Name: Prostatic Acid Phosphatase Antibody Clone PASE/4LJ

    Description and Applications: Anti-PSAP reacts with prostatic acid phosphatase in the glandular epithelium of normal and hyperplastic prostate, carcinoma of the prostate and metastatic cells of prostatic carcinoma. This marker may be helpful in pinpointing the site of origin in cases of metastatic carcinoma of the prostate, and is considered a more sensitive marker than PSA. However, it also offers less specificity. Nevertheless, PSAP complements PSA in the right clinical context.

    Composition: Anti-human Prostatic Acid Phosphatase mouse monoclonal antibody purified from serum and prepared in 10mM PBS, pH 7.4, with 0.2% BSA and 0.09% sodium azide

  • igd
    آنتی بادیهای ایمونوهیستوشیمی

    آنتی ­بادی Human IgD (Polyclonal)

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    Name: IgD Antibody (Polyclonal)

    Description and applications: Anti-IgD antibody reacts with surface immunoglobulin IgD delta chains. This antibody is useful when identifying leukemias, plasmacytomas, and B-cell lineage derived lymphomas (in particular Marginal Zone Lymphoma). Cytoplasmic staining is easily identified on paraffin tissue. Surface immunoglobulin is dificult to demonstrate on paraffin sections but can be demonstrated on frozen sections.

    Composition: anti-human IgD rabbit polyclonal antibody purified from serum and prepared in 10mM PBS, pH 7.4, with 0.2% BSA and 0.09% sodium azide

  • IgG
    آنتی بادیهای ایمونوهیستوشیمی

    آنتی­ بادی Human IgG (E20-V)

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    Name: IgG Antibody Clone E20-V

    Description and applications: The antibody labels the IgGs contained in the plasma cells and their precursors. In general, membrane bound immunoglobulins, extracellular immunoglobulins bound to connective tissue or blood vessels, and immunocomplexes can only be demonstrated in frozen tissues. Plasma cells may not
    be intensely stained in frozen tissue since the immunoglobulins are distributed diffusely through the cytoplasm of these cells. This antibody is useful for identifying leukemias, plasmacytomas and B cells derived from Hodgkin lymphomas. Due to the restrictions on the expression of light and heavy chains in these diseases, demonstration of B-cell lymphomas is possible with clonal rearangements studies. Another application is

    Composition: Anti-human IgG rabbit monoclonal antibody purified from serum and prepared in 10mM PBS, pH 7.4, with 0.2% BSA and 0.09% sodium azide.

  • IgM 1 (2)
    آنتی بادیهای ایمونوهیستوشیمی

    آنتی­ بادی Human IgM (Polyclonal)

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    Name: IgM Antibody (Polyclonal)

     Description and applications: Anti-IgM antibody reacts with surface immunoglobulin IgM mu chains. IgM is one of the predominant surface immunoglobulins on B-lymphocytes. This antibody is useful when identifying lymphomas, plasmacytomas, and B-cell lineage derived Hodgkin’s lymphomas. Due to the restricted expression of heavy and light chains in these diseases, demonstration of B-cell lymphomas is possible with clonal gene rearrangement studies.

    Composition: Anti-human IgM rabbit polyclonal antibody purified from serum and prepared in 10mM PBS, pH 7.4, with 0.2% BSA and 0.09% sodium azide

  • IgG4 (4)
    آنتی بادیهای ایمونوهیستوشیمی

    آنتی ­بادی IgG4 (EP138)

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    Name: IgG4 Antibody Clone EP138

    Description and applications: Human IgG4, one of four subclasses of IgG, contains a gamma 4 heavy chain and a hinge region that is shorter than that of IgG1. No allotypes have been detected on the heavy chains of IgG4. Its two primary effector functions are activating complements and binding to the FcgR of effector cells to initiate phagocytosis. Human IgG4 accounts for less than 6% of the total IgG serum level. Recent studies show that serum levels and immunohistochemistry staining with IgG4 antibody is a useful diagnosis marker for IgG4-related sclerosing diseases. A new concept of IgG4-related systemic disease (ISD) has been established recently. The ISD is characterized by elevated serum IgG4 levels and extensive IgG4+ plasma cell infiltrate in pancreas and/or in other organs, including peripancreatic tissue, bile duct, gallbladder, portal area of the liver, gastric mucosa, colonic mucosa, salivary glands, lymph nodes, and bone marrow. Immunohistochemistry analysis of IgG4 is useful for identifying ISD.

    Composition: anti-human IgG4 rabbit monoclonal antibody purified from serum and prepared in 10mM PBS, pH 7.4, with 0.2% BSA and 0.09% sodium azide.

     

     

  • Immunoglobulin J chain (SP105)
    آنتی بادیهای ایمونوهیستوشیمی

    آنتی ­بادی Immunoglobulin J chain (SP105)

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    Name: J Chain Immunoglobulin Antibody Clone SP105

    Description and applications: J chain is a small glycopeptide and is structurally unrelated to heavy or light chains, but is synthesized by all plasma cells that secrete polymeric immunoglobulins. J chain is linked to IgA and IgM by disulfide bonds, however, it has been detected in IgG- and IgD-containing cells. J chains are present in a large proportion of the immunoglobulin-positive cells in the germinal centers of the tonsil and lymph node. B cells secrete J chain at an early stage of differentiation with the expression persisting in those cells destined to produce IgA or IgM. It has been shown that a significant proportion of mesangial immunoglobulin deposits of IgA nephropathy are dimeric and therefore positive for this antibody.

    Composition: anti-human J Chain immunoglobulin rabbit monoclonal antibody purified and prepared in 10mM PBS, pH 7.4, with 0.2% BSA and 0.09% sodium azide.

     

  • imp3
    آنتی بادیهای ایمونوهیستوشیمی

    آنتی ­بادی IMP 3 (EP286)

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    Name: IMP 3 Antibody Clone EP286

    Description and applications: IMP-3, known as Insulin-like growth factor 2 (IGF-II) mRNA-binding protein 3, is an oncofetal protein that stabilizes IGF-II mRNA for trafficking and plays an important role in cell growth and migration. This 65- 70 kDa protein is expressed normally in developing tissues during early embryogenesis in a variety of fetal tissues including the liver, lung kidney, thymus, and placenta, but at low or undetectable levels in normal adult tissues. Recent studies have demonstrated IMP-3 expression in various malignant tumors of the lung, gastrointestinal tract, liver, endometrium, and bladder, while undetectable in adjacent benign tissues. IMP-3 may have a critical role in tumor proliferation, invasion and metastasis, and has been suggested to be an independent marker for poor prognosis in patients with clear cell carcinomas.

    Composition: Anti-human IMP 3 rabbit monoclonal antibody purified from serum and prepared in 10mM PBS, pH 7.4, with 0.2% BSA and 0.09% sodium azide.

     

  • inhibin
    آنتی بادیهای ایمونوهیستوشیمی

    آنتی­ بادی Inhibin Alpha (R1)

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    Name: Inhibin Alpha Antibody (Clone R1)

    Description and applications: This antibody recognizes the 32kDa alpha subunit of human inhibin. Inhibin alpha is expressed in a range of tissues including prostate, brain, adrenal gland, testis and ovary. The antibody may be of value in the differentiation of adrenocortical tumors, placental and gestational trophoblastic lesions and sex cord stromal tumors.

    Composition: anti-human Inhibin alpha mouse monoclonal antibody purified from ascites. Prepared in 10mM PBS, pH 7.4, with 0.2% BSA and 0.09% sodium azide.

     

     

  • Insulin (2)
    آنتی بادیهای ایمونوهیستوشیمی

    آنتی­ بادی Insulin (EP125)

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    Name: Insulin Antibody Clone EP125

    Description and applications: Insulin is a hormone that regulates glucose homeostasis. It increases cell permeability to monosaccharides, amino acids and fatty acids, and it accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver. It is synthesized in the beta cell of the pancreas. The antibody labels both normal and neoplastic insulinproducing cells. It is useful in identifying insulinoma.

    Composition: Anti-human Insulin rabbit monoclonal antibody purified from serum and prepared in 10mM PBS, pH 7.4, with 0.2% BSA and 0.09% sodium azide.

     

  • Involucrin
    آنتی بادیهای ایمونوهیستوشیمی

    آنتی­ بادی Involucrin (SY5)

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    Name: Involucrin Antibody Clone SY5

    Description and applications: Involucrin is expressed in a range of stratified squamous epithelia, including the cornea. In normal epidermis, it is first expressed in the upper spinous layers, and in keratinocyte cultures it is expressed by all cells that have left the basal layer. Involucrin expression is abnormal in squamous cell carcinomas and premalignant lesions, and is reduced in severe dysplasias of the larynx and cervix.

    Composition: Anti-human Involucrin mouse monoclonal antibody purified from serum and prepared in 10mM PBS, pH 7.4, with 0.2% BSA and 0.09% sodium azide.

     

     

  • ki67 (2)
    آنتی بادیهای ایمونوهیستوشیمی

    آنتی‌ بادی KI 67 (SP6)

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    Name: Rabbit Anti-Human Ki-67 Monoclonal Antibody clone SP6

    Description and aplications: This rabbit monoclonal antibody (clone SP6) reacts with a nuclear antigen which is expressed in every proliferating human cell. It is expressed mainly during the cell cycle phases, including late G1, S, G2 and M phase. The cells in the G0 phase (quiescent cells) are not immunostained. This antibody is useful to identify the degree of cell proliferation. Is a marker to define the growth fraction in benign and malignant tissues, such as prostate, breast or lymphoid tissues. Therefore, it can play an important role as a predictor of malignancy.

    Composition: anti-Ki67 rabbit monoclonal antibody obtained from supernatant culture and prediluted in a tris buffered solution pH 7.4 containing 0.375mM sodium azide solution as bacteriostatic and bactericidal.

    Intended use : Immunohistochemistry (IHC) on paraffin embedded tissues. Not tested on frozen tissues or Western-Blotting

    Immunogen: Synthetic peptide derived from the Cterminus of human Ki67 protein

    Species reactivity: In vitro diagnostics in humans. Not tested in other species

  • LH (2)
    آنتی بادیهای ایمونوهیستوشیمی

    آنتی­ بادی LH (Luteinizing Hormone) (Polyclonal)

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    Name: LH (Luteinizing Hormone) Antibody (Polyclonal)

    Description and applications: This antibody reacts with the human luteinizing hormone (LH). The adenohypophysis produces six main hormones: prolactin (PRL), growth hormone (GH), adrenocorticotropic hormone (ACTH), thyroid stimulating hormone (TSH), follicle-stimulating hormone (FSH) and luteinizing hormone (LH). The
    producing cells (approximately 10%) of the two latest hormones are located in the pars tuberalis of the hypophysis. The glycoprotein hormones LH, FSH and TSH are heterodimers with a common alpha subunit and a solely beta subunit that gives a biochemical, immunological and functional specificity as hormone. The LH induces the secretion of sex steroids in the gonads of both sexes; the Leydig cells of the testicle respond synthesizing testosterone and in the ovary, the theca cells respond synthesizing estrogens and inducing ovulation. The luteinizing hormone (LH) is a glycoprotein secreted by both normal and neoplasic hypophysary cells. Therefore, it can be detected in hypophysary adenomas derived from these cells that correspond to chromophobe cells. They represent approximately 6% of hypophysary adenomas.
    The LH/FSH secreting adenomas have a slow growth and, at the moment of the diagnosis, are usually large, although they are rarely associated with high serum levels of gonadotropins. The adenomas that only secrete LH are rare. The null cell adenomas and oncocytomas, that do not prove clinically nor biochemically hormone production, show focal expression of LH, FSH, TSH and alpha subunit.

    Composition: anti-human LH (Luteinizing Hormone) rabbit polyclonal antibody purified from serum and prepared in 10mM PBS, pH 7.4, with 0.2% BSA and
    0.09% sodium azide.

    Immunogen: Purified luteinizing hormone from the human hypophysis.

  • Keratin 18 Monoclonal Antibody
    آنتی بادیهای ایمونوهیستوشیمی

    آنتی ­بادی Cytokeratin 18 (DC-10)

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    Name: Keratin 18 Antibody Clone DC-10

    Description and applications: The nomenclature coined in 1982 by Moll and Franke assigned ranges from 1 to 8 for keratin type II (neutral or basic) and between 9 and 21 for type I (acidic). However and because of the high homology among the different molecules is common for a single monoclonal antibody to react with different types of keratins , for example keratin brand AE1 keratins 10, 14 , 15, 16 and 19. This antibody reacts with the acid intermediate filament protein of 45 kDa keratin, identified as Keratin 18. Keratin 18 is generally co-expressed with the keratin 8 in most simple gland epithelia. In general, the keratin 18 does not react with squamous multilayered epithelium. In neoplastic tissues, this antibody reacts with different benign and malignant epithelial lesions. Most adenocarcinomas and basal cell carcinomas express this keratin, whereas it is absent in squamous cell carcinomas.

    Composition: anti-Keratin 18 mouse monoclonal antibody obtained from supernatant culture and prediluted in a tris buffered solution pH 7.4 containing 0.375mM sodium azide solution as bacteriostatic and bactericidal. The amount of the active antibody in the sample is 3,3 μg/mL..

    Immunogen: Human breast cancer PMC 42 cells.

  • Lin28 seminoma
    آنتی بادیهای ایمونوهیستوشیمی

    آنتی­ بادی LIN-28 (EP150)

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    Name: LIN-28 Antibody Clone EP150

    Description and applications: LIN28 is a highly conserved, RNA-binding protein (RBP). It plays an important role as a translational enhancer, leading specific mRNAs to polysomes and therefore increasing the competence of protein synthesis. LIN28 was identified as a negative regulator of miRNA biogenesis and suggested to play a central role in blocking miRNAmediated differentiation in stem cells and certain cancers. LIN28 is expressed by various undifferentiated embryonic cell types. Anti- LIN28 has been used as a sensitive marker for germ cell tumors. The positive staining of LIN28 in yolk sac tumors showed an advantage over OCT4, which is negative in these tumors.

    Composition: Anti-human LIN-28 rabbit monoclonal antibody purified from serum and prepared in 10mM PBS, pH 7.4, with 0.2% BSA and 0.09% sodium azide.

     

  • آنتی بادیهای ایمونوهیستوشیمی

    آنتی­ بادی Lysozyme (Polyclonal)

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    Name: Lysozyme Antibody (Polyclonal)

    Description and applications: Lysozyme is one of the anti-microbial agents found in human milk, and is also present in spleen, lung, kidney, white blood cells,
    plasma, saliva, and tears. Missense mutations in LYZ have been identified in heritable renal amyloidosis. Lysozyme is synthesized predominantly in reactive histiocytes rather than in resting, unstimulated phagocytes. Anti-lysozyme stains myeloid cells, histiocytes, granulocytes, macrophages, and monocytes. It is an important marker that may demonstrate the myeloid or monocytic nature of acute leukemia. Anti-lysozyme may aid in the identification of histiocytic neoplasias, large lymphocytes, and classifying lymphoproliferative disorders.

    Composition: anti-human Lysozyme rabbit polyclonal antibody purified from serum and prepared in 10mM PBS, pH 7.4, with 0.2% BSA and 0.09% sodium azide

     

  • آنتی بادیهای ایمونوهیستوشیمی

    آنتی­ بادی Cytokeratin 5 (SP27)

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    Name: Cytokeratin 5 Antibody Clone SP27

    Description and applications:Twenty human keratins are divided into acidic (pI <5.7) and basic (pI >6.0) subfamilies. Members of the acidic and basic subfamilies are found together in pairs. The composition of keratin pairs varies with the epithelial cell type, stage of differentiation, cellular growth environment, and disease state. Many studies have shown the usefulness of keratins as markers in
    cancer research and tumor identification. Point mutations in keratin 5 gene can cause various types of epidermolysis bullosa simplex. Keratin 5 is expressed in most epithelial cells, prostate basal cells and epithelial and biphasic mesotheliomas.

    Composition: Anti-human Cytokeratin 5 rabbit monoclonal antibody purified from serum and prepared in 10mM PBS, pH 7.4, with 0.2% BSA and 0.09% sodium azide.

    Immunogen: Synthetic peptide from Cterminus of human cytokeratin 5.

     

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