Name: Rabbit anti-human PGP 9.5 Antibody (Polyclonal)
Description and aplications: This antibody recognises a molecule with a molecular mass of 27 kDa known as “Protein Gene Product 9.5” or PGP 9.5 and encoded by the UCHL1 (ubiquitin carboxy-terminal hydrolase L1 isoenzyme) gene, located in the chromosomal region 4p13. This protein catalyses the hydrolysis of ubiquitin’s C-terminal esters and amides, playing an important role in protein degradation. Overexpression of the UCHL1 gene occurs in several neoplasms, including leukaemias, carcinomas, and several tumours of mesenchymal origin. In normal tissues, PGP 9.5, which shows mainly a cytoplasmic staining pattern, is present in neurons and nerve fibres of the central and peripheral nervous systems, as well as in numerous neuroendocrine cells, except those of the digestive tract, of which only the pancreatic islets of Langerhans show consistent positive staining. Other normal tissues that are usually stained are segments of renal tubules, spermatogonias and Leydig cells, smooth muscle, and germinal centres.
Composition: anti-human PGP 9.5 rabbit polyclonal antibody purified from serum and prepared in 10mM PBS, pH 7.4, with 0.2% BSA and 0.09% sodium azide
Immunogen: Immunogen: Recombinant protein corresponding to the total length of human protein PGP 9.5.