Name: Rabbit Anti-Human PRAME 1 Monoclonal Antibody (Clone EPR20330)
Description and aplications: The PReferentially expressed Antigen in MElanoma (PRAME), or LB33-E antigen, is part of the family of melanoma nuclear proteins recognized by cytolytic T lymphocytes and is encoded by a gene of the same
name (PRAME) located on chromosomal region 22q11.22. The PRAME protein has been characterized as a dominant inhibitor of the retinoic acid receptor, thus participating in the blockade of cell proliferation, differentiation or apoptosis induced by retinoic acid through the RARA, RARB and RARG receptors. Thus, overexpression of PRAME in tumor cells confers a survival advantage over normal cells. In melanomas, PRAME inhibition restores retinoic acid signaling an reinstates the sensitivity of tumor cells to the antiproliferative effects of this molecule.
Composition: Anti-human PRAME 1 rabbit monoclonal antibody obtained from ascitic and prepared in 10mM PBS, pH 7.4, with 0.2% BSA and 0.09% sodium azide.