Name: Rabitt anti-human SOX9 Antibody (Clon EP317)
Description and aplications: SOX9 is a nuclear transcription factor involved in the differentiation of the chondrocytes and the skeleton as well as of sexual development. The factor is encoded by the gene with the same name located in the chromosome region 17q24.3. This gene encodes a peptide consisting of 509 amino acids containing a
domain homologous to SRY. The co-expression of the genes SOX9 and COL2A1 as well as the overexpression of the first, which is induced by the fibroblast growth factor of primordial chondrocytes, intervenes in the differentiation into mature chondrocytes. About the latter ones, SOX9 interacts additionally with the parathyroid hormone related protein (PTHRP) and helps in keeping its phenotype, inhibiting maturation of hypertrophic chondrocytes. In the determination of the sex of the product of fertilization, SOX9 intervenes together with the steroidogenic factor 1 (SF-1), most probably through SRY gene, functioning as an essential factor in the differentiation of Sertoli cells. The transient activation of the SRY gene of the Y chromosome initializes a set of interactions leading to the formation of the testicle from the undifferentiated gonad; so SOX9 plays a crucial role in this pathway. In fact, the SOX9 gene is overexpressed during the activation of the SRY gene with transfer of its protein from a cytoplasmic to a nuclear location. In contrast, in the female gonad, the SOX9 gene is regulated downwards.
Composition: anti-human SOX9 rabbit monoclonal antibody purified from serum and prepared in 10mM PBS, pH 7.4, with 0.2% BSA and 0.09% sodium azide