Name: Mouse anti-human Tyrosinase Monoclonal Antibody (Clone T311)
Description and aplications: Melanin synthesis by melanocytes comprises a cascade of reactions involving a family of enzymes. One of the key enzymes is tyrosinase. L-tyrosine is the initial substrate for melanin synthesis and its conversion to dopaquinone is catalysed by tyrosinase, the expression of which is therefore a marker of melanocytes and melanoma.
Tyrosinase deficiency is associated with various forms of albinism, specially oculocutaneous albinism. This antibody is useful for the identification of melanocytic tumours and it may be used in combination with other markers such as Melan A. Both markers are expressed in 80-100% of melanoma cases.
Composition: Anti-human Tyrosinase mouse monoclonal antibody purified from serum and prepared in 10mM PBS, pH
7.4, with 0.2% BSA and 0.09% sodium azide
Immunogen: Recombinant protein corresponding to the tyrosinase molecule.