.(Name: Granzyme B Antibody (Clone GZB01
Description and aplications: This antibody reacts with human Granzyme B. Granzyme B is a neutral serine protease which is stored in granules of specialized cytotoxic T lymphocytes (CD8) and NK cells. From mouse CD8 and NK cells vaious types of granzymes have been identifies and named alphabetically (A-G). They are involved in the apoptosis mediated by the cytotoxic lymphocytes. The exocytosis of granules containing granzyme in the cytoplasm of the target cells leads to DNA fragmentation and subsequent apoptosis. Granzyme B has also been located in EBV positive Reed Sternberg cells of Hodgkin’s disease.
Composition: anti-Granzyme B mouse monoclonal antibody obtained from supernatant culture and prediluted in a tris buffered solution pH 7.4 containing 0.375mM sodium azide solution as bacteriostatic and bactericidal.
Immunogen: Recombinant protein encoding the N-terminus of the mature granzyme B.