آنتی بادی Stathmin 1 (STMN1) (SP49)

Name: Rabbit Anti-Human Stathmin 1 (STMN1) Monoclonal Antibody (Clone SP49) 

Description and aplications: Stathmin 1 [also known as leukemia-associated phosphoprotein p18 (LAP18), metablastin or OP18] is a cytosolic protein of 18kDa involved in the regulation of the filament system of micotubules (MTs), destabilizing them after the sequestration of molecules of the tubulin. Its production is coded by the STM1 gene located in the chromosome region 1p36.11. The protein prevents the assembly and supports the disassembly of microtubules. Ser-16 phosphorylation might be necessary to form axons during neurogenesis. Furthermore, many different phosphorylated forms can be observed depending on specific combinations among the locations that can be phosphorylated. MAPK is responsible for the phosphorylation of the stathmin in response to NGF. Ser-16 phosphorylation seems to be necessary for the polarization of neurons (by similarity). Ser-63 phosphorylation reduces 10-fold the binding of  tubulin and suppresses the inhibition of the polymerization of the MTs. It is involved in the control of the learned and innate fear.

Composition: anti-Stathmin 1 rabbit monoclonal antibody obtained from supernatant culture and prediluted in a tris buffered solution pH 7.4 containing 0.375mM sodium azide solution as bacteriostatic and bactericidal.

Immunogen: Synthetic peptide among the amino acids 1 to 100 of the C-terminal subunit of the human Stathmin 1