TLE1 (Transducin-Like Enhancer of Split 1) is a transcriptional corepressor involved in the regulation of gene expression during embryonic development and cell differentiation. It interacts with signaling pathways such as Wnt and Notch to modulate cell growth and differentiation.
TLE1 is best known as a sensitive immunohistochemical marker for synovial sarcoma with strong expression in most cases.