آنتی بادی Pan-TRK کلون QR008 برند Quartett

Pan-TRK is a marker for the proteins Trk A, B and C. Neurotrophic tyrosine kinase receptor (NTRK) is a family of 3 proto-oncogenes including NTRK1, NTRK2, and NTRK3 which encode Trk A, Trk B, and Trk C proteins, respectively. The latter are involved in biological processes such as neuronal survival, differentiation, and plasticity under physiological circumstances. In various cancers, oncogenic fusions involving the kinase domain of NTRK1, 2, or 3 are present. Recently, detecting NTRK fusions has become increasingly important as Trk inhibitors have a high response rate for patients with NTRK fusions. Specific staining patterns appear to correlate with the subcellular localization of the fusion partners.