Name: CD117/c-kit Antibody (Clone EP10)
Description and applications: This antibody reacts with human oncoprotein c-kit (CD117). The proto-oncogene c-kit encodes a transmembrane receptor with tyrosine kinase activity, c-kit (CD117), which is closely related to the family of platelet derived growth factor receptors. c-KIT is involved in hematopoiesis, gametogenesis and melanogenesis. This antigen is expressed in the normal breast epithelium, melanocytes, mast cells and glia. This antibody is recommended to identify oncoprotein expression c-kit in a variety of normal and neoplastic tissues, including gastrointestinal stromal tumors (GIST). It is also expressed in testicular seminoma, small cell carcinomas of the lung, breast carcinomas, glioblastomas, melanomas, and chronicmyeloid leukemias or acute myeloid leukemias in myeloid blast crisis.
Composition: anti-human CD117/c-kit rabbit monoclonal antibody purified from ascites. Prepared in 10mM PBS, pH 7.4, with 0.2% BSA and 0.09% sodium azide.