آنتی ­بادی CD123 (Interleukin-3 Receptor Alpha Chain) (7G3)

Name: CD123 (Interleukin-3 Receptor Alpha Chain) Antibody (Clone 7G3)

Description and applications: The 7G3 monoclonal antibody specifically reacts with human CD123, the 70 kDa IL-3 Receptor α (IL-3Rα) chain. CD123 associates with CD131, the 120-140 kDa Common β chain to form the IL-3 Receptor Complex. CD131 is shared with the receptors for interleukins IL-5 and GM-CSF. IL-3Rα is expressed on hematopoietic progenitors and plays an important role in hematopoietic progenitor cell growth and differentiation. It is also expressed by mast cells, macrophages and a CD5+ B cell subset. This antibody has been reported to block the binding of 125I-IL-3 to high and low affinity IL-3 receptors. In functional experiments, this antibody was found to inhibit acute myeloid leukemia cell proliferation, basophil histamine release, endothelial cell-mediated IL-8 secretion, and neutrophil transmigration.The antibody is useful in paraffin sections to identify plasmacytoid dendritic cells, a distinct lineage of dendritic cells which are considered to gives rise to the blastic plasmacytoid dendritic cell neoplasia (CD4 + / CD56 + / CD123 +) and acute leukemia of ambiguous lineage (CD4 + / CD56- / CD123 +). Plasmacytoid dendritic cells (CD123 +) can be found in clumps in ocational cases os myeloid sarcoma with inv (16) and in chronic myelomonocytic leukemia.

Composition: anti-human CD123 mouse monoclonal antibody purified from ascites. Prepared in 10mM PBS, pH 7.4, with 0.2% BSA and 0.09% sodium azide.