Name: Antibody S100 Protein clone 4C4.9
Description and aplications:
S100 belongs to the family of calcium binding proteins such as calmodulin and troponin C. S100A is composed of an alpha and beta chain whereas S100B is composed of two beta chains. S100 protein is also expressed in the antigen presenting cells such as the Langerhans cells in skin and interdigitating reticulum cells in the paracortex of lymph nodes. The S100 antibody staines schwannomas, ependymomas, astrogliomas, most melanomas and their metastases. It is also characteristic in adipose and chondroid tissue benign and malignant neoplasms. It can also be used as a myoepithelial marker for breast pathology diagnostic. Therefore, this antibody is useful for the identification of malignant melanomas, neuroectodermal, adipocytic and chondroid tumors. This antibody has a cross-reactivity with smooth muscle fibers that can be visible in some occasions.
Composition: anti-human S100 Mouse monoclonal antibody purified from ascites. Prepared in 10mM PBS, pH 7.4, with 0.2% BSA and 0.09% sodium azide