آنتی‌ بادی CGA (Glycoprotein Hormone Alpha) (EP3373)

Name : Rabbit anti-human CGA (Glycoprotein Hormone Alpha) Monoclonal Antibody clone EP3373

Description and applications: CGA belongs to the glycoprotein hormones alpha chain family, which includes the alpha subunits of chorionic gonadotropin (CG), luteinizing hormone (LH), follicle-stimulating hormone (FSH), and thyroidstimulating hormone (TSH). Glycoprotein hormones have the most complex chemical structures of the classical protein hormones. They are dimers consisting of alpha and beta subunits that are covalently associated. These hormones share the same alpha subunit; however, their beta chains are unique and confer them biological specificity. These hormones are essential for the complex endocrine system, which regulates normal growth, sexual development, and reproductive function.The gene encoding the chorionic gonadotropin alpha chain is located on the chromosome region 6q14.3. Hormones LH, FSH, and TSH are secreted by the anterior pituitary, whereas CG is secreted by the placenta. Immunohistochemical detection of chorionic gonadotropin alpha and beta subunits is observed in most non-functional pituitary adenomas, whereas only about 0.6% of these adenomas express the alpha subunit exclusively. In serum, hypersecretion of chorionic gonadotropin alpha subunit is observed in more than 65% of non-functional adenomas, which makes this antibody a useful tool for confirming diagnosis.

Composition: Anti-human CGA rabbit monoclonal antibody purified from serum and prepared in 10mM PBS, pH 7.4, with 0.2% BSA and 0.09% sodium azide

Intended use: Immunohistochemistry (IHC) on paraffin embedded tissues. Not tested on frozen tissues or Western-Blotting

Immunogen: Synthetic peptide corresponding to human protein CGA residues.