دسته: آنتی بادیهای ایمونوهیستوشیمی

Specification:

Anti-BCA-225 antibody recognizes a human breast carcinoma associated glycoprotein BCA-225 (220-225kD). This protein differs in size and distribution from other breast carcinoma antigens. Unlike other antibodies against breast carcinoma antigens, this antibody does not react with benign or malignant colonic, stomach, prostate, liver, pancreas, thyroid, or parotid tissues. Adenocarcinomas of the lung, ovary and endometrium also stain with this antibody.

Immunogen:

A synthetic peptide

Presentation:

Purified antibody with 0.2% BSA and 15mM sodium azide.

Specification:

CD1a is a non-polymorphic major histocompatibility complex class I-related cell surface glycoprotein (45 to 55 kDa) and is expressed in association with β-microglobulin. In normal tissues, anti-CD1a reacts with cortical thymocytes, Langerhans cells, interdigitating dendritic cells, and rare antigen-presenting cells of the lymph node. Anti-CD1a labels Langerhans cell histiocytosis (Histiocytosis X), extranodal histiocytic sarcoma, a subset of T-lymphoblastic lymphoma/leukemia, and interdigitating dendritic cell sarcoma of the lymph node. When combined with antibodies against TTF-1 and CD5, anti-CD1a is useful in distinguishing between pulmonary and thymic neoplasms since CD1a is consistently expressed in thymic lymphocytes in both typical and atypical thymomas, but only focally in 1/6 of thymic carcinomas and not in lymphocytes in pulmonary neoplasms. Anti-CD1a was reported to be a new marker for perivascular epithelial cell tumor (PEComa).

Presentation:

Tris Buffer, pH 7.3-7.7, with 1% BSA and <0.1% Sodium Azide

Specification:

It recognizes a muco-protein of 38-43kDa, which is identified as Podoplanin (PDPN). It localizes in stromal cells of peripheral lymphoid tissue and thymic epithelial cells. As a regulator of the lymphatic endothelium, Podoplanin probably plays a role inthe maintaining the unique shape of podocytes. It is selectively expressed in lymphatic endotheliomas well as lymphoangiomas, Kaposi sarcomas and in the subset of angiosarcomas with probable lymphatic differentiation. Recent studies have also shown Podoplanin to be a highly sensitive and relatively specific marker for epithelioid mesothelioma. Therefore, it can be used in a panel to distinguish mesotheliomas or mesothelial cells from pulmonary carcinomas.

Presentation:

Bioreactor Concentrate with 0.05% BSA and 0.05% Azide

Specification:

Glypican-3 (GPC3) is a glycosylphospatidyl inositol-anchored membrane protein, which may also be found in a secreted form. Recently, GPC3 was identified to be useful tumour marker for the diagnosis of HCC, hepatoblastoma, melanoma, testicular germ cell tumours, and Wilms tumour. In patients with HCC, GPC3 was overexpressed in neoplastic liver tissue and elevated in serum but was undetectable in normal liver, benign liver, and the serum of healthy donors. GPC3 expression was also found to be higher in HCC liver tissue than in cirrhotic liver or liver with focal lesions such as dysplastic nodules and areas of hepatic adenoma (HA) with malignant transformation. In the context of testicular germ cell tumours, GPC3 expression is up regulated in certain histologic subtypes, specifically yolk sac tumours and choriocarcinoma. A high level of GPC3 expression has also been found in some types of embryonal tumours, such as Wilms tumour and hepatoblastoma, with a low or undetectable expression in normal adjacent tissue. Together these studies indicate that GPC3 is an important tumour marker.

Immunogen:

A recombinant fragment containing amino acids 511-580 of human glypican-3

Presentation:

Bioreactor Concentrate with 0.05% Azide

Specification:

CD7 antigen is a cell surface glycoprotein of 40 kD expressed on the surface of immature and mature T-cells as well as natural Killer (NK) cells. It is a member of the immunoglobulin gene superfamily and is the first T-cell lineage associated antigen to appear in T-cell ontogeny, being expressed in T-cell precursors (preceding CD2 expression), and in myeloid precursors, in fetal liver and bone marrow, and persisting in circulating mature T-cells. While its precise function is not known, it is suggested that the molecule functions as an Fc receptor for IgM. CD7 is the most consistently expressed T-cell antigen in lymphoblastic lymphomas/ leukemias and is therefore anti-CD7 is a useful marker in the identification of such neoplastic proliferations. In mature post-thymic T-cell neoplasms, CD7 is the most common pan-T antigen to be aberrantly expressed, which is a useful pointer to a neoplastic T-cell process. CD7 has been shown to be immunoexpressed in 85% of mature peripheral T-cells, the majority of post-thymic T-cells, NK cells, T-cell lymphoblastic leukemia/lymphoma, acute myeloid leukemia, and chronic myelogenous leukemia, CD7 is conspicuously absent in adult T-cell leukemia/lymphoma and is not expressed in mycosis fungoides.

Immunogen:

A synthetic peptide corresponding to residues of human CD7 protein

Presentation:

Antibody in Tris Buffer, pH 7.3-7.7, with 1% BSA and <0.1% Sodium Azide