| Clone | QR017 |
|---|---|
| REF | C-A001 |
| Dilution | 1:100 – 1:200 |
| Immunogen | Synthetic peptide of human ALK |
| Isotype | IgG |
| Species of origin | Rabbit |
Anaplastic lymphoma kinase (ALK) belongs to the insulin receptor superfamily acting as a transmembrane receptorprotein-tyrosine kinase. In normal tissues, ALK protein is expressed only few cells within the developing and mature nervous system. ALK can be active in cancer through multiple mechanisms. The most common mechanism is through the formation of a fusion protein from chromosomal translocations. The protein expression by tumor cells is an independent prognostic factor that predicts a favorable outcome. ALK staining is positive in 50-60% of anaplastic large cell lymphoma (ALCL). NSCLC is found to express ALK 3-7%.
