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Anaplastic lymphoma kinase (ALK) belongs to the insulin receptor superfamily acting as a transmembrane receptorprotein-tyrosine kinase. In normal tissues, ALK protein is expressed only few cells within the developing and mature nervous system. ALK can be active in cancer through multiple mechanisms. The most common mechanism is through the formation of a fusion protein from chromosomal translocations. The protein expression by tumor cells is an independent prognostic factor that predicts a favorable outcome. ALK staining is positive in 50-60% of anaplastic large cell lymphoma (ALCL). NSCLC is found to express ALK 3-7%.

Arginase (ARG) is a manganese metalloenzyme that is part of the urea cycle. It catalyses the conversion of L-arginine to L-ornithine and urea. ARG-1 and ARG-2 are the two isoforms of ARG. ARG-1 is a cytosolic enzyme expressed in liver. The ARG-1 antibody is a sensitive marker of hepatic differentiation and is useful in the detection of hepatocytes in normal tissue as well as granulocytes in peripheral blood. For the identification of hepatocellular carcinoma ARG-1 is a sensitive and specific marker.

Bcl6 is a regulatory gene encoding a zinc finger protein. It plays a key role in the formation of the germinal center (GC) and acts as a regulator of B lymphocyte growth and development by protecting GC-B cells from DNA damage-induced apoptosis. Bcl-6 is mainly expressed in GC-B cells. Surrounding mantle-zone and marginal-zone B cells, plasma cells, and progenitor B cells are negative for Bcl-6. The antibody Bcl-6 detects GC cells in lymphoid follicles and a variety of lymphomas including follicular lymphomas, diffuse large B-cell lymphomas (DLBCL) and Burkitt’s lymphomas. In contrast, Bcl-6 is not expressed in hairy cell leukemias, mantle cell or peripheral lymphomas. Bcl-6 is not restricted to the B cell line, but could also be detected in anaplastic large cell lymphoma. Furthermore, Bcl-6 is involved in mammary epithelial differentiation, which could play a potential role in carcinogenesis.

BOB.1 is a lymphoid-specific transcriptional coactivator, which interacts with the transcription factors Oct-1 andOct-2. BOB.1 is expressed in germinal center B-cells, mantle B-cells and plasma cells. It detects a variety of B-cell lymphomas and Hodgkin’s lymphoma.

Anti-human antibody for immunohistochemical use. The primary antibody is intended for qualitative detection of antigens in formalin-fixed, paraffin-embedded (FFPE) tissue sections. The antibody may be used manually or with any automated staining platform. Authorized and skilled personnel may only use the product. The clinical interpretation of any test results should be evaluated within the context of the patient’s medical history and other diagnostic laboratory test results. A qualified pathologist must perform evaluation.

CD117, also known as c-Kit, encodes a receptor tyrosine kinase that is activated by its ligand stem cell factor (also known as mast cell growth factor). CD117 plays an important role in vital functions, such as homeostasis and melanogenesis. In normal tissues, expression is found in interstitial cells of Cajal, mast cells, melanocytes, various epithelia, testicular and ovarian interstitial cells, neurons of the central nervous system, immature myeloid cells, trophoblastic cells, fetal (but not mature) endothelial cells and fetal (but not mature) basal cells of the skin. CD117 does not occur in smooth muscle cells.
CD117 is a proto-oncogene. Mutations and overexpression are associated with several cancer types, including gastrointestinal stromal tumors (GIST) with 80 95% expression and seminoma with > 90% expression.
CD117 is expressed in around 15-30% of melanomas, although this can vary depending on the type of melanoma. About 30% of lung adenocarcinoma show expression of CD117.

Keratins are cytoplasmic intermediate filament proteins expressed by epithelial cells and their neoplasms. Cytokeratin 20 is a type I keratin mainly found in the gastric and intestinal mucosa. Antibody Cytokeratin 20 is useful in the detection of a variety of adenocarcinomas arising from epithelia, such as colorectal carcinomas, transitional-cell and Merkel cell carcinomas, gastric and pancreatic tumors. CK20 is often used in a panel with antibody Cytokeratin 7.

CD79a (mb-1) is an integral membrane protein expressed early in B cell maturation and next to CD75b (B29) one of two polypeptide chains of the CD79 molecule.The dimer of CD79a/b has the function to transmit signals to the B cell receptor signaling complex into the cell for induction of B cell activation. The CD79a antibody is used as a marker for identification of normal and neoplastic B lymphocytes.