آنتی بادی P40 کلون QR020 برند Quartett

p40, also known as deltaNp63, is an isoform of TP63 that lacks the transactivation domain. p40 is expressed in the nucleus of the normal breast myoepithelium and in the epidermal cells of the skin. In tumor tissues p40 staining is observed in lung and cervical squamous cell carcinoma. p40 antibody recognizes the shortest variant of human p53 and can be a valuable marker in cases where p63 has been used traditionally. The transcription factor p63 was identified as a p53 homolog. p63 is currently the most commonly used marker for squamous cell carcinoma of the lung (SqCC). In a recent study, the p40 staining was equivalent to the sensitivity to SqCC of p63 but was significantly better specific than p63. This report strongly supports the routine use of p40 as an alternative to p63 in the diagnosis of pulmonary squamous cell carcinoma. p40 can prove to be an important antibody in the differential diagnosis of lung adenocarcinoma against lung SqCC.