| Clone | QR108-QM006 |
|---|---|
| REF | C-P012 |
| Dilution | 1:100 – 1:200 |
| Immunogen | Synthetic peptides of human AMACR and p63 |
| Isotype | AMACR; IgG; p63: IgG2a/k |
| Species of origin | AMACR: Rabbit; p63: Mouse |
AMACR is an important enzyme for the b-oxidation of branched-chain fatty acids. High expression of the AMACR protein is found in prostate cancer (88-94%), but not in normal prostate and benign prostate diseases. The expression of AMACR is also detected in premalignant lesions of the prostate, in prostatic intraepithelial neoplasia (PIN) the positive rate of AMACR ranges from 13-72%. The p63 protein, a homolog of the tumor suppressor p53, is highly expressed in the basal or precursor layer of many epithelial tissues. p63 is detected in the basal cells of the prostate in normal prostate glands and PIN. Prostate adenocarcinoma is almost always negative for p63. The combination of AMACR and p63 can be extremely useful in the diagnosis of PIN and small focus adenocarcinomas, especially in difficult cases and cases with limited tissue. AMACR stains the cytoplasm of prostate adenocarcinomas and PIN, while p63 stains the basal cell nuclei of PIN and benign prostate glands.
