آنتی­ بادی COX-2 (SP21)

Name: COX2 (Cyclooxygenase 2) Antibody (Clone SP21)

Description and applications: COX-2 (Cyclooxygenase-2) is an inducible enzyme. It is involved in the response of cells to growth factors, tumor promoters, and cytokines that induce its expression. Given its role in synthesizing prostaglandins, COX-2 is therefore of interest in studying immune response regulation. COX-2 is induced by a wide variety of stimuli and was initially identified as immediate-early growth response gene. In addition, COX-2 expression markedly increased in 85-90% of human colorectal adenocarcinoma whereas COX-1 levels remain unchanged. COX-2 is expressed in normal cells from mammary acini, uterine cervix, uterus, fallopian tubes, trophoblast of chorionic villi, prostate, seminal vesicles, epididymis, bladder urothelial epithelium, gastric glands or gallbladder. Consequently, COX-2 is expressed in many solid tumors. Intense to moderate cytoplasmic and sometimes membrane expression is observed in colorectal, prostate, cervical, endometrial, ovarian, urothelial, pancreatic and hepatic carcinomas. COX-2 is frequently expressed in breast carcinomas while up to 80% of pituitary adenomas are positive. The prognostic value of COX-2 expression is controversial.

Composition: anti-human COX2 rabbit monoclonal antibody purified by protein affinity and prepared in 10mM PBS, pH 7.4, with 0.2% BSA and 0.09% sodium azide.

Immunogen: Synthetic peptide corresponding to C-terminus of rat COX-2.