آنتی بادی SF1 – FACTOR 1 ESTEROIDOGÉNICO (N1665)

Name: Mouse anti-Steroidogenic Factor 1 Monoclonal Antibody (clone N1665) 

Description and aplications: Steroidogenic factor 1 (SF-1), also known as Ad4BT (adrenal 4 binding protein) or NR5A1 (nuclear receptor subfamily, group 5, member 1) is a transcription factor that belongs to the nuclear receptor superfamily and functions as a key regulator in the development and function of the adrenal gland and the male reproductive system after the enzymatic control of the biosynthesis of corticosteroids and aldosterone. It also intervenes at pituitary level for the development of the gonads. SF-1 is encoded by the NR5A1 gene, located in the region q33 of chromosome 9. It is a gene of 22kb containing 7 exons. Mutations of the gene are responsible for the development of dysgenetic gonads and ovarian insufficiency in women or female gonads or ambiguous gonads in men. It is also responsible for the absence of puberty and infertility, especially in men.

Composition: Mouse anti-Steroidogenic Factor 1 (SF1) monoclonal antibody obtained from purified ascitic fluid and prepared in 10mM PBS, pH 7.4, with 0.2% BSA and 0.09% sodium azide.