آنتی‌ بادی Pax-5 (MX017)

 Name: PAX-5 Antibody clone MX017

Description and applications: The PAX-5 gene is essential for B-cell differentiation. There are at least four isoforms, of which PAX-5a has been most studied. PAX-5 encodes the 50 kDa B-cell specific activator protein, BSAP. PAX-5 is expressed by pro-, pre-, and mature B-cells, but is downregulated during terminal differentiation of plasma cells. PAX-5 influences the expression of other B-cell specific genes, including CD19 and CD20 and CD79a, preceding the expression of CD20. PAX-5 is silenced at the plasma cell stage under the influence of Blymphocyte-induced maturation protein-1 (PRDM1). Pax-5 is consistently expressed in mature B cell lymphomas. It is useful to distinguish between classical Hodgkin lymphoma (+) and ALCL (-). In Hodgkin lymphoma, the neoplastic cells show a weaker staining compared with the accompanying B cells. Occasionally it expressed in acute myeloid leukemias especially those with t (8; 21). CD20 negative B-cell lymphomas of patients treated with anti-CD20 monoclonal antibodies, maintain PAX5 staining the antibody representing a good tool to confirm their cell of origin. Pax-5 expression was detected in hyperplastic mesonephric remains, epididymitis, neurons of the adult nervous tissue, small cell carcinomas, Merkel cell tumor and other neuroendocrine tumors.

Composition: anti-human PAX5 mouse monoclonal antibody purified from serum and prepared in 10mM PBS, pH 7.4, with 0.2% BSA and 0.09% sodium azide