| Clone | QR035 |
|---|---|
| REF | C-E004 |
| Dilution | 1:100 – 1:200 |
| Immunogen | Synthetic peptide of human E-Cadherin |
| Isotype | IgG |
| Species of origin | Rabbit |
E-cadherin is a transmembrane protein that is important for epithelial cell adhesion. It maintains the structural and functional integrity of epithelial tissues. Reduced or aberrant E-cadherin expression breaks cell to cell contacts, and thus, cells acquire the ability to migrate. In normal tissues, E-cadherin is localized to the membrane of epithelial cells, consistent with its role in cell adhesion. In tumor tissues, E-cadherin stains positively in the glandular epithelium and adenocarcinomas of the lung, gastrointestinal tract, and ovary. It has also been shown to be positive in some thyroid carcinomas. The antibody has been useful in distinguishing adenocarcinoma from mesothelioma. In combination with p120 or cytokeratin it involves the differentiation of ductal (E-cadherin positive) and lobular (E-cadherin negative) breast carcinoma. Several studies have reported that reduced E-cadherin expression is correlated with poor prognosis in several types of carcinomas.
