Specification:
Androgen Receptor belongs to the super-family of nuclear hormone receptors that employ complex molecular mechanisms to guide the development and physiological functions of their target tissues. Androgen Receptor function plays a pivotal role in normal prostate development and physiology as well as prostrate tumorigenesis. Androgen stimulates results in cell proliferation in both developing prostate and the malignant prostrate. Androgen Receptor is a phosphoprotein and also regulates mitogen-activated protein kinase (MAP Kinase). The inhibition f the MEK1/2 pathway correlates directly with a change in phosphorylation state of the androgen receptor. In prostate cancer, Androgen Receptor has been proposed as a marker of the hormone responsiveness.
Immunogen:
Synthetic peptide derived from near N-terminus of human Androgen Receptor.
Presentation:
Purified antibody is diluted in Tris-HCL buffer containing stabilizing protein and <0,1% Sodium Azide.
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