دسته بندی: آنتی بادیهای ایمونوهیستوشیمی
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آنتی بادیهای ایمونوهیستوشیمیآنتی بادی Inhibin Alpha کلون INHA/4265 برند Patho Sage
Specification:
It recognizes a 47kDa protein, which is identified as alpha sub-unit of Inhibin. It is a gonadal protein that preferentially suppresses the secretion of pituitary follicle-stimulating hormone (FSH). Inhibin comprises two subunits, Inhibin A and Inhibin B. Each subunit consists of the same subunit, covalently linked to 1 of 2 distinct subunits, – or -. Originally isolated from ovarian follicular fluid and characterized as a disulphide-linked dimeric glycoprotein, inhibin belongs to the transforming growth factor (TFG) superfamily. Antibodies against Inhibin are useful in making a differentiation between adrenal cortical tumors and renal cell carcinoma. Sex cord stromal tumors of the ovary as well as trophoblastic tumors also demonstrate cytoplasmic positivity. Inhibin antibody is also used to make the differential diagnosis of intra-uterine vs. ectopic pregnancy in endometrial curetting.
Immunogen:
A synthetic peptide (around aa 73-96) of α-subunit of human inhibin A protein (exact sequence is proprietary)
Presentation:
Bioreactor Concentrate with 0.05% Azide
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آنتی بادیهای ایمونوهیستوشیمیآنتی بادی CD31 (PECAM-1) کلون JC/70A برند Patho Sage
Specification:
CD31 (PECAM-1) is a transmembrane glycoprotein member of the immunoglobulin supergene family of adhesion molecules. It is widely used as an endothelial cell marker. CD31 Ab reacts with normal, benign, and malignant endothelial cells which make up blood vessel lining. The level of CD31 expression can help to determine the degree of tumor angiogenesis, and a high level of CD31 expression may imply a rapidly growing tumor and potentially a predictor of tumor recurrence.
Immunogen:
Membrane preparation of a spleen from a patient with hairy cell leukemia
Presentation:
Bioreactor Concentrate with 0.05% Azide
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آنتی بادیهای ایمونوهیستوشیمیآنتی بادی Cytokeratin 8/18 کلون K.8 + DC10 برند Patho Sage
Specification:
Cytokeratin 8 (CK8) belongs to the type II (or B or basic) subfamily of high molecular weight cytokeratin’s and exists in combination with cytokeratin 18 (CK18). This MAb cocktail recognizes all simple epithelia including glandular epithelium, for example thyroid, female breast, gastrointestinal tract, respiratory tract, and urogenital tract including transitional epithelium. All adenocarcinomas and most squamous carcinomas are positive but keratinizing squamous carcinomas are usually negative. This antibody is useful in demonstrating the presence of Paget cells; there is very little keratin 18 in the normal epidermis so only Paget cells are stained. Immunohistochemical staining with this MAb is indistinguishable from that obtained with monoclonal antibody 5D3.
Immunogen:
Keratin preparation from a human carcinoma (K8.8); PMC-42 human breast carcinoma cells (DC10)
Presentation:
Protein A/G purified antibody from Bioreactor Concentrate with 0.05% BSA and 0.05% Azide.
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آنتی بادیهای ایمونوهیستوشیمیآنتی بادی Cytokeratin PAN کلون LU5 برند Patho Sage
Specification:
Monoclonal antibody Lu-5 reacts with an epitope which is common to all cytokeratins respectively with a cytokeratin associated protein. The antigen recognized by anti-cytokeratin pan is present in all types of epithelia. It recognizes most subtypes of cytokeratins in cryofixed and paraffin sections and is ideally suited as a first order pan-epithelial marker. The epitope recognized by Lu-5 is a formalin-resistant marker of great value in tumor diagnosis, located on the surface of cytokeratin filaments. It has been preserved during vertebrate evolution and can be shown in all species from amphibia to man. The epitope is present in most cytokeratin polypeptides of both the acidic (type I) and basic (type II) subfamily but does not occur in other cytoskeletal proteins. The epithelial specificity and the broad tissue and species cross reactivity provide an excellent probe for the differential diagnosis of epithelial versus mesenchymal tumors, large cell lymphomas and neural tumors.
Immunogen:
Lung tumor cell lines A549 and A2182
Presentation:
Concentrated cell culture supernatant in phosphate buffered saline pH 7.2 (PBS), and 0.05% sodium azide as a preservative
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آنتی بادیهای ایمونوهیستوشیمیآنتی بادی MELAN A (MART1) کلون M2-9E3 برند Patho Sage
Specification:
This antibody recognizes a protein doublet of 20-22kDa, identified as MART-1 (Melanoma Antigen Recognized by T cells 1) or Melan-A. MART-1 is a newly identified melanocyte differentiation antigen recognized by autologous cytotoxic T lymphocytes. Seven other melanoma associated antigens recognized by autologous cytotoxic T cells include MAGE-1, MAGE-3, tyrosinase, gp100, gp75, BAGE-1, and GAGE-1. Subcellular fractionation shows that MART-1 is present in melanosomes and endoplasmic reticulum. This MAb labels melanomas and other tumors showing melanocytic differentiation. It is also a useful positive marker for angiomyolipoma’s. It does not stain tumor cells of epithelial, lymphoid, glial, or mesenchymal origin.
Immunogen:
Recombinant hMART-1 protein
Presentation:
Bioreactor Concentrate with 0.05% Azide
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آنتی بادیهای ایمونوهیستوشیمیآنتی بادی CDX2 کلون MonoPoly/6271R برند Patho Sage
Specification:
The specificity of this monoclonal antibody to its intended target was validated by HuProt TM Array, containing more than 19.000 full-length human proteins. The intestine-specific transcription factors CDX1 and CDX2 are important for directing intestinal development, differentiation, proliferation and maintenance of the intestinal phenotype. CDX2 protein expression has been seen in GI carcinomas. Anti-CDX2 has been useful to establish GI origin of metastatic adenocarcinoma and carcinoids and is especially useful in distinguish metastatic colorectal adenocarcinoma from lung adenocarcinoma. However, mucinous carcinomas of the ovary also expressed CDX2 protein. It limits the usefulness of this marker in the distinction of metastatic colorectal adenocarcinoma from mucinous of the ovary.
Immunogen:
Recombinant fragment and/of synthetic peptides of human CDX2 protein
Presentation:
Bioreactor Concentrate with 0.05% Azide