Specification:
Recognizes a protein of -55kDa, identified as SOX I 0. This MAb is highly specific and does not cross-react with other members of the SOX-family. SOX genes comprise a family of genes that are related to the mammalian sex-determining gene SRY. These genes similarly contain sequences that encode for the HMG-box domain, which is responsible for the sequencespecific DNA binding activity. SOX-10 is a sensitive marker of melanoma, including conventional, spindled,and desmoplastic subtypes. It is expressedby metastatic melanomas and nodal capsular nevusin sentinel lymph nodes, but notby other lymph node componentssuch asdendritic cells, which usually express S I 00protein. Commonly used melanoma markers, such as anti-HMB-45andanti-Melan-A, are poorly expressed in desmoplasticmelanomas while SOX-10 is moderately to strongly expressed in desmoplastic melanomas. SOX- 10 is considered as a very reliable marker for recognizing residual desmoplastic melanomas. In normal tissues, it is expressed in Schwann cells, melanocytes, and myoepithelial cells of salivary, bronchial and mammary glands. SOX-I 0 expression is also observed in mast cells.
Immunogen:
Recombinant fragment (155 Amino residues between aa 100-300) of human SOX10 protein
Presentation:
Bioreactor Concentrate with 0.05% Azide
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