فلوسایتومتری

FITC anti-mouse/human CD11b Antibody

Company:BioLegend

Catalog Number : 101205

Size : 50 µg

Clone : M1/70

Isotype : Rat IgG2b, κ

Reactivity : Mouse, Human, Cross-Reactivity: Chimpanzee, Baboon, Cynomolgus, Rhesus, Rabbit (Lapine)

Description :

CD11b is a 170 kD glycoprotein also known as αM integrin, Mac-1 α subunit, Mol, CR3, and Ly-40. CD11b is a member of the integrin family, primarily expressed on granulocytes, monocytes/macrophages, dendritic cells, NK cells, and subsets of T and B cells. CD11b non-covalently associates with CD18 (β2 integrin) to form Mac-1. Mac-1 plays an important role in cell-cell interaction by binding its ligands ICAM-1 (CD54), ICAM-2 (CD102), ICAM-4 (CD242), iC3b, and fibrinogen.

FITC F(ab’)2 Goat anti-human IgG Fcγ Antibody

Company:BioLegend

Catalog Number: 398006

Size : 100 µg

Clone : Poly23980

Isotype : Goat Polyclonal Ig

Reactivity : Human

Description :

gG Fc is a homodimer that is composed of the constant region of the two heavy chains that form the IgG molecule. The Fc fragment mediates opsonization, antibody dependent cellular cytotoxicity (ADCC), and complement activation through binding to Fc receptors such as CD16, CD32, CD64, and the complement factor C1.

PE anti-human CD79a (Igα) Antibody

Company:BioLegend

Catalog Number : 333503

Size: 25 tests

Clone : HM47

Isotype : Mouse IgG1, κ

Reactivity: Human

Description:

CD79a is a 47 kD type I integral membrane protein, also known as mb-1 or Iga. It is a member of the Ig superfamily and disulphide-associated with CD79b (B29). The interaction of CD79a/CD79b heterodimer with B cell suface Ig forms B cell antigen complex. CD79a is expressed in B cells from early pre-B to plasma cell stage. It has been shown that CD79a is also weakly expressed in some precursors of T- and myeloid cells. CD79 mediates the transport of IgM to B cell surface and transduces signals initiated by BCR aggregation.

PE anti-mouse Ly-6G/Ly-6C (Gr-1) Antibody

Company:BioLegend

Catalog Number : 108407

Size : 50 µg

Clone : RB6-8C5

Isotype : Rat IgG2b, κ

Reactivity : Mouse

Description :

Gr-1 is a 21-25 kD protein also known as Ly-6G/Ly-6C. This myeloid differentiation antigen is a glycosylphosphatidylinositol (GPI)-linked protein expressed on granulocytes and macrophages. In bone marrow, the expression levels of Gr-1 directly correlate with granulocyte differentiation and maturation; Gr-1 is also transiently expressed on bone marrow cells in the monocyte lineage. Immature Myeloid Gr-1+ cells play a role in the development of antitumor immunity.

PE anti-TCF1 (TCF7) Antibody

Company:BioLegend

Catalog Number : 655208

Size : 100 tests

Clone : 7F11A10

Isotype : Mouse IgG1, κ

Reactivity : Human

Description :

TCF1 is the first identified member of the T-cell-specific transcription factor family. It plays an important role in T cell development and differentiation. TCF1 is inactivated by association with the transcriptional repressor TLE proteins. During Wnt signaling, the transcriptional coactivator CTNNB1 accumulates and, in turn, replaces the transcriptional repressor associated with TCF1. Interaction with CTNNB1 results in transactivation of TCF1 target genes. Deletion of TCF1 causes massive apoptosis of double positive thymocyte, suggesting that TCF1 is required for thymocyte survival during T cell development. In addition to its function in thymus, TCF1 promotes T cell differentiation to Th2 cells in the periphery through transcriptional activation of GATA3.

PE/Cyanine5 anti-human CD3 Antibody

Company:BioLegend

Clone: HIT3a

Isotype: Mouse IgG2a, κ

Cat Number: 300309

Reactivity: Human

Antibody Type: Monoclonal

Description:

CD3ε is a 20 kD chain of the CD3/T-cell receptor (TCR) complex which is composed of two CD3ε, one CD3γ, one CD3δ, one CD3ζ (CD247), and a T-cell receptor (α/β or γ/δ) heterodimer. It is found on all mature T lymphocytes, NK-T cells, and some thymocytes. CD3, also known as T3, is a member of the immunoglobulin superfamily that plays a role in antigen recognition, signal transduction, and T cell activation.