دسته بندی: ایمونو هیستوشیمی
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آنتی بادیهای ایمونوهیستوشیمیآنتی بادی CEA(Carcinoembryonic Antigen) کلون CEA31 برند Patho Sage
Specification:
This antibody recognizes proteins of 80-200kDa, identified as different members of CEA family. CEA is synthesized during development in the fetal gut and is re-expressed in increased amounts in intestinal carcinomas and several other tumors. This MAb does not react with nonspecific cross-reacting antigen (NCA) and with human polymorphonuclear leucocytes. It shows no reaction with a variety of normal tissues and is suitable for staining of formalin/paraffin tissues. CEA is not found in benign glands, stroma, or malignant prostatic cells. Antibody to CEA is useful in detecting early foci of gastric carcinoma and in distinguishing pulmonary adenocarcinomas (60-70% are CEA+) from pleural mesotheliomas (rarely or weakly CEA+).
Immunogen:
Human colon carcinoma extract
Presentation:
Bioreactor Concentrate with 0.05% Azide
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آنتی بادیهای ایمونوهیستوشیمیآنتی بادی CEA(Carcinoembryonic Antigen) کلون Col-1 برند Patho Sage
Specification:
CEA (carcinoembryonic antigen, CD66) consists of a heterogeneous family of related oncofetal 200 kD glycoproteins that is secreted into the glycocalyx surface of gastrointestinal cells. The staining of CEA is considered important because: 1. In breast carcinomas, CEA staining correlated well with clinical outcome, independent of histologic type of tumors (with or without metastases). 2. A CEA-staining primary tumor usually shows CEA elevations when there is disease recurrence or progression. 3. Before proceeding with extensive or repeated blood monitoring of CEA as an index of biological activity of diseases, it is important to find out if the substance is present in the original malignant lesion, preferably at the time of biopsy. 4. Excellent correlation between CEA staining of primary and metastatic tumors (including micrometastases to the regional lymph nodes) has been observed with respect to cervical, colonic and ovarian carcinomas. Usually CEA is demonstrated as a linear labeling of the apical poles of cells lining the glandular lumen and, occasionally, as weak staining near the apex of colonic epithelial cells. More uniform cytoplasmic staining is a feature of more aggressive tumors. CEA, however, should not be used as a marker of differentiation because many colon and lung tumors actually show increased staining with differentiation. Pancreatic carcinomas, testicular tumor, gall bladder neoplasms and granular cell Myo blastomas stain positive, whereas malignant tumors of brain, prostate, skin, lymphoreticular tissues, hepatocellular carcinomas, esophageal squamous cell carcinomas, and mesothelioma fail to stain for CEA.
Immunogen:
Human colon carcinoma extract
Presentation:
Bioreactor Concentrate with 0.05% Azide
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آنتی بادیهای ایمونوهیستوشیمیآنتی بادی DOG1(Anoctamin 1) کلون DG1/1484 برند Patho Sage
Specification:
Expression of DOG-1 protein is elevated in the gastrointestinal stromal tumors (GIST’s), KIT signaling-driven mesenchymal tumors of the GI tract. DOG-1 is rarely expressed in other soft tissue tumors, which, due to appearance, may be difficult to diagnose. Immunoreactivity for DOG-1 has been reported in 97.8 percent of scorable GIST’s, including all KIT negative GIST’s. Overexpression of DOG-1 has been suggested to aid in the identification of GISTs, including Platelet-Derived Growth Factor Receptor Alpha mutants that fail to express KIT antigen. The overall sensitivity of DOG1 and KIT in GIST’s is nearly identical: 94.4% vs. 94.7%.
Immunogen:
Recombinant human DOG-1 protein
Presentation:
Bioreactor Concentrate with 0.05% Azide
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آنتی بادیهای ایمونوهیستوشیمیآنتی بادی P53 کلون DO7 برند Patho Sage
Specification:
Anti-p53 Tumor Suppressor Protein antibody recognizes a 53 kDa phosphoprotein, identified as p53 suppressor gene product. It reacts with the mutant as well as wild form of p53. Positive nuclear staining with this antibody has been shown to be a negative prognostic factor in Breast carcinoma, Lung carcinoma, colorectal, and Urothelial carcinoma. p53 positivity has also been used to differentiate Uterine serous carcinoma from endometrioid carcinoma as well as to detect Intratubular germ cell neoplasia.
Immunogen:
Recombinant human wild type p53 protein expressed in E. coli.
Presentation:
Bioreactor Concentrate with 0.05% Azide
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آنتی بادیهای ایمونوهیستوشیمی
آنتی بادی DOG1(Anoctamin 1) کلون DOG1.1 برند Patho Sage
Specification:
Expression of DOG-1 protein is elevated in the gastrointestinal stromal tumors (GIST’s), KIT signaling-driven mesenchymal tumors of the GI tract. DOG-1 is rarely expressed in other soft tissue tumors, which, due to appearance, may be difficult to diagnose. Immunoreactivity for DOG-1 has been reported in 97.8 percent of scorable GIST’s, including all KIT negative GIST’s. Overexpression of DOG-1 has been suggested to aid in the identification of GISTs, including Platelet-Derived Growth Factor Receptor Alpha mutants that fail to express KIT antigen. The overall sensitivity of DOG1 and KIT in GIST’s is nearly identical: 94.4% vs. 94.7%.
Immunogen:
A synthetic peptide from human DOG-1 protein, conjugated to a carrier protein
Presentation:
Bioreactor Concentrate with 0.05% Azide
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آنتی بادیهای ایمونوهیستوشیمی
آنتی بادی CD19 کلون EP169 برند Patho Sage
Specification:
CD19 is expressed only on B-cells and follicular dendritic cells. It is a specific and sensitive marker of B-cells widely expressed from early pre-B stages, normal B-cells and normal plasma cells. It is considered a positive regulator of both intrinsic and stimulus-dependent pathways in B-lymphocytes. CD19 is useful in identification of B-cell lineage of majority of B-cell neoplasms but appears to be less useful in subclassifying of B-cell neoplasms in histological material. It appears to be potentially useful additional marker of follicular dendritic cell tumors.
Presentation:
Phosphate buffered Saline (PBS), pH 7.2 with 1% BSA and <0,1% Sodium Azide
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آنتی بادیهای ایمونوهیستوشیمی
آنتی بادی Factor 13a کلون EP3372 برند Patho Sage
Specification:
Factor 13 (plasma transglutaminase, fibrin stabilizing factor) is a plasma protein that plays an important role in the final stages of blood coagulation and fibrinolysis. It circulates in blood as a tetramer consisting of two “A” and two “B” subunits. The amino acid sequence of the enzymatically active subunit, Factor 13a, is unique and does not exhibit internal homology, but its active center is like that of the thiol proteases. Factor 13a is activated by thrombin and calcium ion to a transglutaminase that catalyzes the cross linking of fibrin molecules, forming intermolecular isopeptide bonds, thus stabilizing blood clots. In two diseases that share some histological resemblance (Lymphocyte-poor graft-versus-hostreaction and toxic epidermal necrolysis), Factor-13a-positive dendrocytes show some morphological changes, probably as a response to altered cytokine environment. Factor-13a-positive dendrocytes thus are reported to possibly play a role in the regulation of the connective tissue remodeling that may accompany epidermal destruction.
Immunogen:
synthetic peptide corresponding to residues in human Factor XIIIa
Presentation:
Rabbit Monoclonal antibody in Tris glycerine Buffer, pH 7.4, containing 0,15M NaCl, 40% Glycerol, 0,05% BSA and 0.01% sodium azide.
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آنتی بادیهای ایمونوهیستوشیمیآنتی بادی Helicobacter Pylori کلون HPLY/7225 برند Patho Sage
Specification:
The spiral shaped bacterium Helicobacter pylori is strongly associated with inflammation of the stomach and is also implicated in the development of gastric malignancy. H. pylori is known to cause peptic ulcers and chronic gastritis in human. It is associated with duodenal ulcers and may be involved in development of adenocarcinoma and low-grade lymphoma of mucosa associated lymphoid tissue in the stomach. This antibody stains the individual H. pylori bacterium when it presents on the surface of the epithelium or in the cytoplasm of the epithelial cells in biopsy tissue sections from the antrum and body of the stomach.
Immunogen:
Recombinant Helicobacter pylori Catalase protein fragment (around aa323-445) (Exact sequence is proprietary)
Presentation:
Bioreactor Concentrate with 0.05% Azide
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آنتی بادیهای ایمونوهیستوشیمیآنتی بادی BCL6 کلون IG191E/A8 برند Patho Sage
Specification:
Bcl-6 is a transcriptional regulator gene which codes for a 706-amino-acid nuclear zinc finger protein. Antibodies to this protein stain the germinal center cells in lymphoid follicles, the follicular cells and interfollicular cells in Follicular Lymphoma, Diffuse Large B-Cell Lymphomas, and Burkitt’s lymphoma, and most of the Reed-Sternberg cells in Nodular Lymphocyte Predominant Hodgkin’s Disease. In contrast, anti-BCL6 rarely stains Mantle Cell Lymphoma and MALT Lymphoma. BCL6 expression is seen in approximately 45% of CD30+ Anaplastic Large Cell Lymphomas but is consistently absent in other peripheral T-cell lymphomas.
Immunogen:
Recombinant BCL-6 protein
Presentation:
Bioreactor Concentrate with 0.05% Azide