دسته: ایمونو هیستوشیمی

Specification:

This antibody recognizes acidic or Type I, or LMW cytokeratin’s which include CK10, CK14, CK15, CK16, and CK19. It has been shown to be useful for marking squamous and adenocarcinoma of the lung, liver carcinoma, breast cancer, and esophageal cancer.

Immunogen:

Human epidermal keratin

Presentation:

The material contains 0.05% sodium azide as a preservative.

Specification:

CD21, also knows as CR2, C3d receptor and EBV receptor, is expressed strongly on mature B cells, follicular dendritic cells and weakly on immature thymocytes and T lymphocytes. In B cell intogeny, cd 21 appears after the pre-B-stage, is maintained during peripheral B-cell development and is lost upon terminal differentiation into plasma cells. CD21 expression is also gradually lost after stimulation of B cells in vitro. CD21 functions as a receptor for C3d, C3dg and iC3b Complement components, for EBV and for IFNaplha. CD21 binds to CD23 and associates with CD19, CD81 and Leu13 to form a large signal-transduction complex involved in B cell activation.

Presentation:

Anti-CD21 is a mouse monoclonal antibody from supernatant diluted in phosphate buffered saline, pH 7.4, with protein base, and preserved with sodium azide

Specification:

This MAb reacts with the rod domain of human cytokeratin-19 (CK19), a polypeptide of 40kDa. Its epitope maps between amino acid 312-335. CK19 is expressed in sweat gland, mammary gland ductal and secretory cells, bile ducts, gastrointestinal tract, bladder urothelium, oral epithelia, esophagus, and ectocervical epithelium. Anti-CK19 reacts with a wide variety of epithelial malignancies including adenocarcinomas of the colon, stomach, pancreas, biliary tract, liver, and breast. Perhaps the most useful application is the identification of thyroid carcinoma of the papillary type, although 50%60% of follicular carcinomas are also labeled. Anti-CK19 is a useful marker for detection of tumor cells in lymph nodes, peripheral blood, bone marrow and breast cancer.

Immunogen:

Human breast cancer MCF-7 cells

Presentation:

Bioreactor Concentrate with 0.05% Azide

Specification:

This antibody has been used for evaluating the primary site of a metastatic carcinoma of unknown origin and distinguishing between benign and malignant lesions. It is believe that CA15-3 reacts primarily with the DF3-antigen, a 300 kDa mucinlike glycoprotein present on the apical border of secretory mammary epithelial cells. CA15-3 has been detected with immunohistochemistry in a wide spectrum of carcinomas, including Breast Carcinomas (ductal and lobular), Sarcomas (Synovial Sarcoma and Malignant Fibrous Histiocytomas), and Lung Carcinomas. CA15-3 can be used as a supplementary marker for epithelial differentiation. CA15-3 does not stain Melanomas or Ewing’s Sarcomas. Approximately 30% of Hepatocellular Carcinomas are positive for CA15-3.

Presentation:

CA15-3 is a mouse monoclonal antibody derived from cell culture supernatant that is concentrated, dialyzed, filter sterilized and diluted in buffer pH 7.5, containing BSA and sodium azide as a preservative.

Specification:

Tryptases constitute a subfamily of trypsin-like proteinases, stored in mast cell secretory granules and basophils. Upon cellular activation, these enzymes are released into the extracellular environment. Anti-tryptase is a good marker for mast cells, basophils, and their derivatives.

Presentation:

Anti-Tryptase is a mouse monoclonal antibody from ascites diluted in phosphate buffered saline, pH 7.3-7.7, with protein base, and preserved with sodium azide

Specification:

Anti CA-125 antibody reacts with epitheloid malignancies of the ovary, papillary serous carcinoma of the cervix, adenocarcinoma of the endometrium, clear cell adenocarcinoma of the bladder, and epitheloid mesothelioma. The antigen is formalin resistant, permitting the detection of ovarian cancer by immunohistochemistry, although serum assays for this protein are widely used to monitor ovarian cancer. Anti CA-125 also reacts with antigens in seminal vesicle carcinoma.

Presentation:

Anti-CA-125 is a mouse monoclonal antibody from ascites diluted in Tris- buffered saline, pH 7.3 – 7.7, with protein base, and preserved with sodium azide.

Specification:

This antibody recognizes a cluster of proteins between 70-80kDa, identified as tyrosinase. Occasionally a minor band at 55kDa is also detected. This MAb shows no cross-reaction with MAGE-1 and tyrosinase-related protein 1, TRP-1/gp75. Tyrosinase is a copper-containing metalloglycoprotein that catalyzes several steps in the melanin pigment biosynthetic pathway: the hydroxylation of tyrosine to L-3,4-dihydroxy-phenylalanine (dopa), and the subsequent oxidation of dopa to dopaquinone. Mutations of the tyrosinase gene occur in various forms of albinism. Tyrosinase is one of the targets for cytotoxic T-cell recognition in melanoma patients. Staining of melanomas with this MAb shows tyrosinase in melanotic as well as amelanotic variants. This MAb is a useful marker for melanocytes and melanomas.

Immunogen:

Recombinant tyrosinase protein

Presentation:

Bioreactor Concentrate with 0.05% Azide