برچسب: BioLegend

APC anti-human CD3

Company: BioLegend

Catalog : 300311, 300312

Size: 25 tests  / 100 tests

 Clone: HIT3a

 Isotype : Mouse IgG2a, κ

 Reactivity: Human

Description:

CD3ε is a 20 kD chain of the CD3/T-cell receptor (TCR) complex which is composed of two CD3ε, one CD3γ, one CD3δ, one CD3ζ (CD247), and a T-cell receptor T-cell heterodimer. It is found on all mature T lymphocytes, NK-T cells, and some thymocytes. CD3, also known as T3, is a member of the immunoglobulin superfamily that plays a role in antigen recognition, signal transduction, and T cell activation.

APC anti-mouse CD8a Antibody

Company:BioLegend

Catalog Number: 100711

Size : 25 µg

Clone : 53-6.7

Isotype : Rat IgG2a, κ

Reactivity : Mouse

Description :

CD8, also known as Lyt-2, Ly-2, or T8, consists of disulfide-linked α and β chains that form the α(CD8a)/β(CD8b) heterodimer and α/α homodimer. CD8a is a 34 kD protein that belongs to the immunoglobulin family. The CD8 α/β heterodimer is expressed on the surface of most thymocytes and a subset of mature TCR α/β T cells. CD8 expression on mature T cells is non-overlapping with CD4. The CD8 α/α homodimer is expressed on a subset of γ/δ TCR-bearing T cells, NK cells, intestinal intraepithelial lymphocytes, and lymphoid dendritic cells. CD8 is an antigen co-receptor on T cells that interacts with MHC class I on antigenpresenting cells or epithelial cells. CD8 promotes T cell activation through its association with the TCR complex and protein tyrosine kinase lck.

FITC anti-human CD2 Antibody

Company:BioLegend

Catalog : 300206

Size : 100 tests

Clone :  RPA-2.10

Isotype  : Mouse IgG1, κ

Reactivity  : Human, African Green, Baboon, Capuchin Monkey, Chimpanzee, Cynomolgus, Pigtailed Macaque, Rhesus, Swine (Pig, Porcine)

Description: 

 CD2 is a 50 kD type I transmembrane glycoprotein also known as LFA-2, T11, and sheep red blood cell receptor (SRBC-R). This immunoglobulin superfamily member is expressed on thymocytes, T lymphocytes, NK cells, and thymic B cell subsets. The major ligand for CD2 is CD58 (also known as LFA-3). CD2 has also been reported to bind CD48, CD59, and CD15. CD2 plays a critical role in alternative T cell activation, T cell signaling, and cell-cell adhesion.

FITC anti-mouse CD4 Antibody

Company:BioLegend

Catalog Number : 100405

Size : 50 µg

Clone : GK1.5

Isotype: Rat IgG2b, κ

Reactivity : Mouse

Description :

CD4 is a 55 kD protein also known as L3T4 or T4. It is a member of the Ig superfamily, primarily expressed on most thymocytes, a subset of T cells, and weakly on macrophages and dendritic cells. It acts as a coreceptor with the TCR during T cell activation and thymic differentiation by binding MHC class II and associating with the protein tyrosin kinase, lck.

FITC anti-mouse CD8a Antibody

Company:BioLegend

Catalog Number : 100705

Size : 50 µg

Clone : 53-6.7

Isotype : Rat IgG2a, κ

Reactivity : Mouse

Description :

CD8, also known as Lyt-2, Ly-2, or T8, consists of disulfide-linked α and β chains that form the α(CD8a)/β(CD8b) heterodimer and α/α homodimer. CD8a is a 34 kD protein that belongs to the immunoglobulin family. The CD8 α/β heterodimer is expressed on the surface of most thymocytes and a subset of mature TCR α/β T cells. CD8 expression on mature T cells is non-overlapping with CD4. The CD8 α/α homodimer is expressed on a subset of γ/δ TCR-bearing T cells, NK cells, intestinal intraepithelial lymphocytes, and lymphoid dendritic cells. CD8 is an antigen co-receptor on T cells that interacts with MHC class I on antigenpresenting cells or epithelial cells. CD8 promotes T cell activation through its association with the TCR complex and protein tyrosine kinase lck.

FITC anti-mouse CD49b (pan-NK cells) Antibody

Company:BioLegend

Catalog Number : 108905

Size : 50 µg

Clone : DX5

Isotype : Rat IgM, κ

Reactivity : Mouse

Description :

DX5 antigen has been recently characterized as CD49b. It is a 150 kD integrin α chain also known as α integrin, VLA-2 α chain, and integrin α chain. CD49b non-covalently associates with CD29 (β integrin) to form the CD49b/CD29 complex known as VLA-2, a receptor for collagen and laminin. CD49b is expressed on platelets, the majority of NK cells, NKT cells, and a small subset of CD8+ T cells (this population can be significantly increased following viral infection). DX5 is used for the identification and isolation of NK cells, and is especially useful for identifying NK cells in mice lacking the NK1.1 antigen.

PE anti-human CD79a (Igα) Antibody

Company:BioLegend

Catalog Number : 333503

Size: 25 tests

Clone : HM47

Isotype : Mouse IgG1, κ

Reactivity: Human

Description:

CD79a is a 47 kD type I integral membrane protein, also known as mb-1 or Iga. It is a member of the Ig superfamily and disulphide-associated with CD79b (B29). The interaction of CD79a/CD79b heterodimer with B cell suface Ig forms B cell antigen complex. CD79a is expressed in B cells from early pre-B to plasma cell stage. It has been shown that CD79a is also weakly expressed in some precursors of T- and myeloid cells. CD79 mediates the transport of IgM to B cell surface and transduces signals initiated by BCR aggregation.

PE anti-mouse CD366 (Tim-3) Antibody

Company:BioLegend

Catalog Number : 119703

Size : 50 µg

Clone : RMT3-23

Isotype : Rat IgG2a, κ

Reactivity : Mouse

Description :

CD366 (Tim-3) is a transmembrane protein also known as T cell immunoglobulin and mucin domain containing protein-3. Tim-3 is expressed at high levels on Th1 lymphocytes and CD11b macrophages. Tim-3 has also been shown to exist as a soluble protein. Cells expressing Tim-3 are present at high levels in the CNS of animals at the onset of experimental autoimmune encephalomyelitis (EAE), a disease mediated by lymphocytes secreting Th1-like cytokines. Tim-3 has been proposed to inhibit Th1-mediated immune responses and promote immunological tolerance.

PE/Cyanine5 anti-human CD3 Antibody

Company:BioLegend

Clone: HIT3a

Isotype: Mouse IgG2a, κ

Cat Number: 300309

Reactivity: Human

Antibody Type: Monoclonal

Description:

CD3ε is a 20 kD chain of the CD3/T-cell receptor (TCR) complex which is composed of two CD3ε, one CD3γ, one CD3δ, one CD3ζ (CD247), and a T-cell receptor (α/β or γ/δ) heterodimer. It is found on all mature T lymphocytes, NK-T cells, and some thymocytes. CD3, also known as T3, is a member of the immunoglobulin superfamily that plays a role in antigen recognition, signal transduction, and T cell activation.

PE/Cyanine5 anti-human CD19 Antibody

Company:BioLegend

Catalog Numbeer: 302209

Size : 25 tests

Clone : HIB19

Isotype: Mouse IgG1, κ

Reactivity: Human, Chimpanzee, Rhesus

Description :

CD19 is a 95 kD type I transmembrane glycoprotein also known as B4. It is a member of the immunoglobulin superfamily expressed on B-cells (from pro-B to blastoid B cells, absent on plasma cells) and follicular dendritic cells. CD19 is involved in B cell development, activation, and differentiation. CD19 forms a complex with CD21 (CR2) and CD81 (TAPA-1), and functions as a BCR coreceptor.

PerCP/Cyanine5.5 anti-mouse CD279 (PD-1) Antibody

Company:BioLegend

Catalog Number : 135207

Size : 25 µg

Clone : 29F.1A12

Isotype : Rat IgG2a, κ

Reactivity : Mouse

Description :

CD279, also known as programmed death-1 (PD-1), is a 50-55 kD glycoprotein belonging to the CD28 family of the Ig superfamily. PD-1 is expressed on activated splenic T and B cells and thymocytes. It is induced on activated myeloid cells as well. PD-1 is involved in lymphocyte clonal selection and peripheral tolerance through binding its ligands, B7-H1 (PD-L1) and B7-DC (PD-L2). It has been reported that PD-1 and PD-L1 interactions are critical to positive selection and play a role in shaping the T cell repertoire. PD-L1 negative costimulation is essential for prolonged survival of intratesticular islet allografts.