آنتی بادی ATRX (POLYCLONAL)

Name: ATRX (POLYCLONAL)

Description and aplications: ATRX, also known as ATP-dependent helicase ATRX, Xlinked helicase II,X-linked nuclear protein or Znf-HX, is encoded by a gene located in the chromosomal region Xq21.1, which undergoes an inactivation and encodes a nuclear and homologous NTP protein with several types of helicases II present at the membrane level. It belongs to the superfamily of proteins similar to the SNF2 subgroup and features a C-terminal region rich in glutamine similar to other nuclear transcription factors. Mutations of the gene cause a severe mental retardation syndrome linked to alphathalassemia (ATR-X syndrome) characterized by severe psychomotor retardation, characteristic facial features, urogenital abnormalities and alpha thalassemia with H hemoglobin inclusions at the erythrocyte level. Other syndromes related to mutations of the ATRX gene have been described such as X-linked mental retardation-hypotonic faciessyndrome or alpha thalassemia myelodysplastic syndrome. After interacting with the DAXX domain and potential binding with the EZH2, the ATRX protein plays several roles in mitosis, rearrangement of the chromatin and transcription as well as in the biology of the telomeric regions.

Composition: Rabbit anti-ATRX plyclonal antibody obtained from purified ascitic fluid and prepared in 10mM PBS, pH
7.4, with 0.2% BSA and 0.09% sodium azide.

Immunogen: Recombinant protein corresponding to the alpha thalassemia X-linked intellectual disability syndrome (ATR-X) subunit.