آنتی بادی BRG1 (EPNCIR111A)

Name: BRG1 (EPNCIR111A)

Description and aplications: BRG1, also known as SMARCA4 or BAF190A, SNF2B and SNF2L4, is a member of the enzymatic chromatin remodeling complex SWI/SNF, where it encodes the catalytic subunit that intervenes in the configuration of nucleosomes, making the transcriptional activation of the complex more accessible. The gene encoding the protein is located in the chromosome region 19p13.2, whose alterations have primarily been associated with the rhabdoid tumor predisposition syndrome-2 and Coffin-Siris syndrome 4. The former is characterized by a predisposition to develop renal or extrarenal rhabdoid tumors as well as a variety of brain tumors among which are choroid plexus carcinoma, meduloblastoma and PNET. CoffinSiris syndrome 4 presents both autosomal recessive and dominant transmission and is characterized by intellectual disability, psychomotor retardation, coarse facial features and multiple congenital malformations such as aplasia or hypoplasia of thedistal phalanx or fifth finger nail. Additionally, cardiac, gastrointestinal, genitourinary or central nervous system malformations may be associated.

Composition: Anti-human BRG1 rabbit monoclonal antibody purified from serum and prepared in 10mM PBS, pH 7.4, with 0.2% BSA and 0.09% sodium azide

Immunogen: Synthetic peptide corresponding to the fraction of amino acids 200-300 of the mouse BRG1.