آنتی ­بادی CD30 (Ber-H2)

Name: CD30 Antibody Clone Ber-H2

Description and aplications: The CD30 antigen (also called Ki-1) is a single chain glycoprotein that belongs to the family of for tumor necrosis receptors factors (TNF)
and acts as a type 1 transmembrane receptor. The gene encoding CD30 has been mapped to chromosome 1p36. The CD30 glycoprotein is synthesized as a 90 kDa precursor that is transformed into the Golgi complex in a mature 105/120 kDa phosphorylated glycoprotein that binds to the cell membrane. In normal tissues CD30 expression is restricted to some immunoblasts (both B and T) located around lymphoid follicles of antigenically stimulated lymphoid tissue, acinar cells of the pancreas and during pregnancy, by some decidual cells. In neoplasms, the CD30 antigen is  expressed in anaplastic tumors, such as the mono- bi- and multinucleated cells of Hodgkin’s disease cells and thevast majority of anaplastic large cell lymphoma, a third of which lack the CD45 immunostaining. The CD30 antigen is also expressed in some non-hematopoietic malignancies such as embryonal carcinomas and rarely in poorly differentiated tumors of epithelial origin or melanocytes. For this reason and for in vitro diagnosis, the CD30 antibody should be used as part of an ample panel of antibodies that rule out the possibility of nonlymphoid origin for positive tumors.

Composition: anti-human CD30 mouse monoclonal antibody purified from ascites fluid by Protein A chromatography. Prepared in 10mM PBS, pH 7.4, with
0.2% BSA and 0.09% sodium azide.

Immunogen: Co cells.