آنتی ­بادی CD56/NCAM-1 (123C3)

Name: CD56/NCAM-1 Antibody Clone 123C3

Description and applications: CD56, known as neural cell adhesion molecule (NCAM), was originally identified in the nervous system and belongs to a group of cell adhesion molecules including cadherins, selectins, and integrins. Anti-CD56 recognizes two proteins of the NCAM, the basic molecule expressed on most neuroectodermally-derived cell lines, tissues and neoplasms (e.g. neuroblastomas, small cell carcinomas). It is also expressed on some mesodermally-derived tumors (rhabdomyosarcoma). Furthermore, anti-CD56 has found great utility in the recognition of NK cell and NK/T-cell lymphomas. It has been shown that 71% of myelomas are positive for anti-CD56 as well. It also offers higher sensitivity in the diagnosis of small cell carcinoma than anti-chromogranin and anti-synaptophysin and has been demonstrated as a useful marker for sex cord gonadal stromal tumors. Light staining of smooth muscle elements may be seen.

Composition: anti-human CD56 rabbit monoclonal antibody purified from ascites. Prepared in 10mM PBS, pH 7.4, with 0.2% BSA and 0.09% sodium azide.