.(Name: ERCC1 Antibody (Clone SP68
Description and applications: Nucleotide Excision Repair (NER) is a versatile mechanism capable of recognizing and eliminating damaged DNA, most commonly caused by UV radiations. ERCC1 is one of the three endonucleases that catalyzes this process. The ERCC1 gene is located on the chromosomal region 19q13.3-q13.2 and encodes a protein of 297 amino acids and about 32.5 kDa molecular weight. Although there are only few immunohistochemical studies with antibodies against ERCC1, it seems that tumors with extensive and intense immunohistochemical expression of this molecule have a worse prognosis and are resistant to platinum-based therapy. These tumors include non-small cell lung adenocarcinomas, gastrointestinal tract adenocarcinomas, breast, urinary bladder and adrenal cortex carcinomas, and advanced stage genital tract carcinomas.
Composition: anti-ERCC1 rabbit monoclonal antibody obtained from supernatant culture and prediluted in a tris buffered solution pH 7.4 containing 0.375mM sodium azide solution as bacteriostatic and bactericidal.
Immunogen: Recombinant human ERCC1 protein.