آنتی ­بادی Galectin-3 (B2C10)

.(Name: Galectin 3  Antibody (Clone B2C10

Description and applications: The antibody recognizes a 30 kDa protein member of the family of the beta-galactosidase-binding lctin involved in cell growth, adhesion, inflammation and apoptosis processes. Galectin-3 is expressed in normal inflammatory cells (granulocytes) in vascular endothelium and in primary and metastatic malignancies of the colon, liver, breast, tongue and thyroid. This antibody is useful for differentiating between benign (adenomas) and thyroid malignancies. It may also be useful for the recognition of minimally invasive thyroid lesions. The combined use of Galectin-3 and HBME-1 may be helpful in the differential diagnosis between adenomas and oncocytic thyroid carcinomas. The sensitivity of galectin-3 to detect oncocytic carcinomas and the oncocytic variant of papillary carcinoma is 95%. The medullary carcinomas and normal thyroid follicles do not express galectin-3.

Composition: anti-Galectin 3 mouse monoclonal antibody obtained from supernatant culture and prediluted in a tris buffered solution pH 7.4 containing 0.375mM sodium azide solution as bacteriostatic and bactericidal.

Immunogen: Recombinant protein of the full length od the human Galectin-3 protein.