آنتی ­بادی Cytokeratin 13 (EP69)

Name: Keratin 13 Monoclonal Antibody Clone EP69

Description and aplications: The nomenclature coined in 1982 by Moll and Franke assigned ranges from 1 to 8 for cytokeratin type II (neutral or basic) and between 9 and 21 for type I (acidic). However and because of the high homology among the different molecules is common for a single monoclonal antibody to react with different types of keratins , for example keratin brand AE1 keratins 10, 14 , 15, 16 and 19. The 54 kD keratin 13 is the major acidic keratin that is assembled in vivo with type 4 and is expressed in the suprabasal cells of the multilayered keratinizing epithelium of mucous membranes, transitional epithelium, pseudostratified epithelium and myoepithelial cells. The monoclonal anti- keratin 13 antibody has been used as a marker for non-keratinized squamous epithelium and is expressed in various squamous metaplasias, but is down regulated in squamous dysplasia and squamous carcinoma. It is useful to identify epithelial derived tumors of the trachea, apocrine and eccrine sweat glands, salivary glands, stem cells of the endocervical glands, bladder, exocervix , tongue, esophagus, anus and basal layer of the epidermis.In addition, mutations in the gene sequence of keratin 13 have been implicated in genetic disease known as autosomal dominant white sponge nevus of the oral cavity.

Composition: anti-Keratin 13 rabbit monoclonal antibody obtained from supernatant culture and prediluted in a tris buffered solution pH 7.4 containing 0.375mM sodium azide solution as bacteriostatic and bactericidal. The amount of the active antibody was not determined.

Immunogen: Synthetic peptide corresponding to human keratin 13 residues.