آنتی­ بادی Mucin 5AC (MUC5AC) (MD-19 also known as MRQ-19)

Name: Mucin 5AC (MUC5AC) Antibody (Clone MUC5AC, MD-19 also known as MRQ-19)

Description and applications: Mucins are glycoproteins of high molecular weight linked to oligosaccharides in the threonine or serine wastes by glycosidic bonds produced by different epithelial cells. In humans, at least 14 genes coding for mucins have been identified (MUC1, MUC2, MUC3, MUC4, MUC5AC, MUC5B, MUC6, MUC7, MUC8, MUC9, MUC11, MUC12, MUC13 and MUC16). Mucins are classified as follows: Membrane-bound mucins (MUC1, MUC3, MUC4, MUC12 and MUC16), secreted mucins forming gel-like secretion (MUC2, MUC5AC, MUC5B, and MUC6) and secreted soluble mucin (MUC7). Mucins are the main component of the mucous membrane that protects the gastric mucosa from the chemical and mechanical insults. This antibody reacts with the mucin 5AC. MUC5AC isthe glycoprotein secreted forming gel-like secretions expressed by the gastric epithelium and the respiratory tract. The distribution of the expression of the mucins is heterogeneous MUC1 (stomach and pancreas), MUC2 (small and large intestine), MUC4 (stomach), MUC5AC (stomach) and MUC6 (stomach, small intestine and pancreas). MUC5AC is expressed in apical rim in normal cells and also in the lateral edges of the cytoplasmic membrane and intracytoplasmically in carcinomas of different tissues. MUC5AC is expressed in normal gastric epithelium in the cardia, fundus and pyloric antrum. Barrett’s esophagus shows positivity for this mucin; MUC5AC is not expressed in the small intestine, large intestine nor pancreas. In neoplastic tissues, it is expressed in pancreatic, colon and appendix adenocarcinomas, extramammary Paget’s disease Colloid carcinomas of the breast nor cholangiocarcinomas in general do not express MUC5AC. The mucin expression pattern in tumors has been associated with the tumor location, the biological insult and the infiltration capacity of some neoplasias.

Composition: Anti-human Mucin 5AC mouse monoclonal antibody purified from serum and prepared in 10mM PBS, pH 7.4, with 0.2% BSA and 0.09% sodium azide.