آنتی بادی PAX5 کلون 24 برند Patho Sage

Specification:

There are at least nine members of the paired box (PAX) gene family whose protein products are transcription factors involved in development. The conserved paired box DNA-binding domain is found in the N-terminal region of Pax proteins. An octomer and homeodomain sequence are conserved in the centre of the proteins. The Ser/Thr/ Pro-rich region in the Cterminal portion contains a conserved 100 amino acid transactivating domain. One of the best studied Pax family members, Pax-5 influences the expression of several B-cell-specific genes, such as CD 19 and CD 20. Pax-5 is expressed primarily in pro-, pre-, and mature B cells, but not in plasma cells. Interestingly, Pax-5 mRNA is transiently detected in the mesencephalon and spinal cord during embryogenesis. Expression then shifts to the fetal liver and correlates with the onset of B lymphopoiesis. PAX-5 has been found to be important in both B cell and nervous system development.

Immunogen:

Human PAX-5 aa. 151-306

Presentation:

0.25 mg/ml in aqueous buffered solution containing BSA, glycerol, and ≤ 0.09% sodium azide