Specification:
TDT is a DNA polymerase that catalyses the addition of deoxynucleotides to free 3’OH groups on polydeoxynucleotide chains. TDT is present in the nucleoli of normal T and B lymphocyte precursors and the neoplastic equivalent. Positive cells are most abundant in normal thymus, especially in the cortex, with little or no labelling of the medulla. A few cells in the normal bone marrow corresponding to hematopoietic precursor cells, also express TDT. TDT is a valuable marker in the identification of immature T and B Lymphocyte precursors and acute leukaemia’s. It is expressed at high level in T cell and pre-B cell acute lymphoblastic leukaemia’s and lymphomas. B-cell ALL and mature (or peripheral) B and T cell malignancies are TDT-negative. TDT may also be expressed in some cases of acute myeloid leukaemia.
Presentation:
Tissue culture supernatant containing 15mM sodium azide.
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