Specification:
The WT1 gene, identified as a tumor suppressor gene located at 11p13, is involved in the development of Wilms’ tumor. The WT1 gene encodes a transcription factor with four DNA-binding zinc fingers at the C terminus. In vitro studies showed that WT1 suppresses or activates a number of genes, including those for PDGF-A chain, EGF receptor, CSF-1, IGF-II, IGF-I receptor, RAR-α, c-myc, bcl-2 and WT1 itself. Immunohistochemically, WT1 is detected in the nucleus of tumor cells of Wilms’ tumor and mesothelioma; therefore, WT1 has traditionally been used as a diagnostic marker for these tumors. Recent reports showed that other types of cancers, such as ovarian serous cancers and rhabdomyosarcomas also express WT1.
Presentation:
Tissue culture supernatant containing 15mM sodium azide
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