آنتی بادی Granzyme B کلون GrB-7 برند Patho Sage

Specification:

Granzymes are serine proteases which are stored in specialized lytic granules of cytotoxic T lymphocytes (CTL) and in natural killer cells. Granzyme B is involved in target cell apoptosis during lymphocyte mediated cyto-toxicity. Exocytosis of granzyme containing granules in the cytoplasm of the target cell will lead to induction of DNA fragmentation and apoptosis  of the target cell. Anti-Granzyme B has been useful in diagnosing Natural killer/T cell lymphoma, as well as anaplastic largecell lymphoma. High percentages of cytotoxic T cells have been shown to be an unfavorable prognostic indicator in Hodgkin’s disease. The monoclonal antibody reacts with the 33 kD human serine protease granzyme B. It does not react with human granzyme A.

Presentation:

Tissue culture supernatant with 0.1% BSA and 0.02% sodium azide