دسته بندی: ایمونوفلورسانس
-
ایمونوفلورسانسآنتی بادی Human Albumin (Polyclonal) -FITC
Anti-Human Albumin
DESCRIPTION AND APPLICATIONS: Albumin is a soluble, monomeric protein which comprises about one-half of the blood serum protein. Albumin functions primarily as a carrier protein for steroids, fatty acids, and thyroid hormones and plays a role in stabilizing extracellular fluid volume. Albumin is synthesized in the liver as preproalbumin which has an N-terminal peptide that is removed before the nascent protein is released from the rough endoplasmic reticulum. The product, proalbumin, is in turn cleaved in the Golgi vesicles to produce the secreted albumin. This antibody should be used in conjunction with a panel of antibodies to aid in the identification of albumin in target tissue (e.g., in the diagnosis of renal or dermal pathologies). The interpretation of the results should be always corroborated with those of external controls and integrated with the morphological and clinical aspectsfor the final diagnosis.
COMPOSITION Anti-human Rabbit Antibody to Albumin. Fluorescein Conjugated Polyclonal antibody purified from serum and prepared in buffer with carrier protein and preservative for stabilization
IMMUNOGEN: Albumin (Human Serum)
-
ایمونوفلورسانسآنتی بادی Human C1q (Polyclonal) -FITC
Anti-Human C1q
DESCRIPTION AND APPLICATIONS :C1q associates with the proenzymes C1r and C1s to yield C1, the first component of the serum complement system. The collagen-like regions of C1q interact with the Ca(2+)-dependent C1r(2)C1s(2) proenzyme complex, and efficient activation of C1 takes place on interaction of the globular heads of C1q with the Fc regions of IgG or IgM antibody present in immune complexes.
C1q is predominantly produced by macrophages but also by follicular dendritic cells, interdigitating cells and cells of the monocyte-macrophage lineage. C1q deficiency has a profound effect on host defence and clearance of immune complexes. Absence of C1q may cause autoimmunity by impairment of the clearance of apoptotic cells. Inherited C1q deficiency is also associated with the development of systemic lupus erythematosus (SLE).
This antibody should be used in conjunction with a panel of antibodies to aid in the identification of C1q fragment in target tissue (e.g., in the diagnosis of renal or dermal pathologies).
The interpretation of the results should be always corroborated with those of external controls and integrated with the morphological and clinical aspects for the final diagnosis
COMPOSITION: Anti-human Sheep Antibody to C1q. Fluorescein Conjugated Polyclonal antibody purified from serum and prepared in buffer with carrier protein and preservative for stabilization.
IMMUNOGEN: Human C1q, purified from plasma
-
ایمونوفلورسانسآنتی بادی Human C3c (Polyclonal) -FITC
Anti-Human C3c
DESCRIPTION AND APPLICATIONS: The complement factor C3 consists of an alpha and a beta chain. C3 is a central factor in the complement cascade. It is central to the alternative pathway that leads to the C3 convertase C3bBb. The classical mannose binding lectin activation pathway leads to the C3 convertase C4b2a. These convertases cleave C3 resulting in C3a and C3b. Further degradation leads to the formation of the alpha chain products C3d, C3g and C3c. C3 is an acute phase protein that is produced by a wide range of tissues, including renal epithelial cells and hepatocytes. This antibody should be used in conjunction with a panel of antibodies to aid in the identification of C3c in target tissue (e.g., in the diagnosis of renal or dermal pathologies). The interpretation of the results should be always corroborated with those of external controls and integrated with the morphological and clinical aspects for the final diagnosis
COMPOSITION Anti-human Sheep Antibody to C3c. Fluorescein Conjugated Polyclonal antibody purified from serum and prepared in buffer with carrier protein and preservative for stabilization.
IMMUNOGEN: Human C3c purified from plasma
-
ایمونوفلورسانسآنتی بادی Human C4 (Polyclonal) -FITC
Anti-Human C4
DESCRIPTION AND APPLICATIONS: This antibody reacts with human C4, C4b, and C4c but does not react with the C4d epitope. Traces of contaminating antibodies have been removed by solid phase absorption with human plasma proteins. This antibody is well suited for tissue section staining but may also be used for other applications.
This antibody should be used in conjunction with a panel of antibodies to aid in the identification of C4c fragment in target tissue (e.g., in the diagnosis of renal or dermal pathologies).
The interpretation of the results should be always corroborated with those of external controls and integrated with the morphological and clinical aspects for the final diagnosis.
COMPOSITION
Anti-human Rabbit Antibody to C4c. Fluorescein Conjugated Polyclonal antibody purified from serum and prepared in buffer with carrier protein and preservative for stabilization
Immunogen
C4c Complement isolated from complement-activated human serum.
-
ایمونوفلورسانسآنتی بادی Human Fibrinogen (Polyclonal) -FITC
Anti-Human Fibrinogen
DESCRIPTION AND APPLICATIONS: Sheep anti Human fibrinogen antibody recognizes human fibrinogen, a complex ~340kDa heterohexameric (ditrimeric) glycoprotein consisting of 3 pairs of α, β and γ chains linked by a series of 29 disulphide bonds. The six chains are arranged in such a way that all the N-Terminal ends adjoin to form a central E domain with two trimeric coiled coil structures connecting to outer D domains. Fibrinogen plays an important role in the coagulation process with the D and E domains interacting via the C Terminal ends of the α chains during fibrin clot cross-linking. Sheep anti human fibrinogen antibody shows minimal cross-reactivity with related serum proteins. Fibrinogen has been identified as a ferritin binding protein in the horse. Sheep anti human fibrinogen antibody has been successfully as a capture reagent for ferritin – anti ferritin IgG complexes in horse plasma to evaluate theantibody response to ferritin by ELISA
This antibody should be used in conjunction with a panel of antibodies to aid in the identification of fibrinogen in target tissue (e.g., in the diagnosis of renal or dermal pathologies).
The interpretation of the results should be always corroborated with those of external controls and integrated with the morphological and clinical aspects for the final diagnosis.
COMPOSITION
Anti-human Sheep Antibody to Fibrinogen. Fluorescein Conjugated Polyclonal antibody purified from serum and prepared in buffer with carrier protein and preservative for stabilization.
IMMUNOGEN: Human fibrinogen purified from plasma.
-
ایمونوفلورسانسآنتی بادی Human Alpha Heavy Chain (IgA) (Polyclonal) -FITC
Anti-Human Alpha Heavy Chain (IgA)
DESCRIPTION AND APPLICATIONS: Ig alpha is the major immunoglobulin class in body secretions. It may serve both to defend against local infection and to prevent access of foreign antigens to the general immunologic system. It is present abundantly in mucous linings of gastrointestinal, respiratory and genitourinary tracts, tears and saliva but not in plasma.
This antibody should be used in conjunction with a panel of antibodies to aid in the identification of immunoglobulin A in target tissue (e.g., in the diagnosis of renal or dermal pathologies).
The interpretation of the results should be always corroborated with those of external controls and integrated with the morphological and clinical aspects for the final diagnosis.
COMPOSITION
Anti-human Sheep Antibody to Immunoglobulin A (IgA). Fluorescein Conjugated Polyclonal antibody purified from serum and prepared in buffer with carrier protein and preservative for stabilization.
IMMUNOGEN: A mixture of purified human IgA myeloma proteins representing both IgA subclasses and light chain types.
-
ایمونوفلورسانسآنتی بادی Human Gamma Heavy Chain (IgG) (Polyclonal) -FITC
Anti-Human Gamma Heavy Chain (IgG)
DESCRIPTION AND APPLICATIONS: Goat anti Human IgG antibody reacts with the heavy chain of human IgG and has been cross-absorbed with human IgM, IgD and IgA, but may recognize IgG from other species.
This antibody should be used in conjunction with a panel of antibodies to aid in the identification of immunoglobulin G in target tissue (e.g., in the diagnosis of renal or dermal pathologies).
The interpretation of the results should be always corroborated with those of external controls and integrated with the morphological and clinical aspects for the final diagnosis.
COMPOSITION
Anti-human Goat Antibody to Gamma Heavy Chain (IgG). Fluorescein Conjugated Polyclonal antibody purified from serum and prepared in buffer with carrier protein and preservative for stabilization
IMMUNOGEN: Normal human IgG and human IgG paraproteins.
-
ایمونوفلورسانسآنتی بادی Human Mu Heavy Chain (IgM) (47.2.E9) -FITC
Anti-Human Mu Heavy Chain (IgM)
DESCRIPTION AND APPLICATIONS: Mouse anti Human IgM antibody, clone 47.2.E9 reacts with human IgM and recognizes the Mu chain.
IgM is expressed intracellularly, during early stages of B lymphopoiesis, and then on the surface of more mature B cells in the bone marrow and peripheral B cells.
This antibody should be used in conjunction with a panel of antibodies to aid in the identification of immunoglobulin M in target tissue (e.g., in the diagnosis of renal or dermal pathologies).
The interpretation of the results should be always corroborated with those of external controls and integrated with the morphological and clinical aspects for the final diagnosis.
COMPOSITION
Anti-human Mouse Antibody to Mu Heavy Chain (IgM). Fluorescein Conjugated Monoclonal antibody purified from serum and prepared in buffer with carrier protein and preservative for stabilization.
IMMUNOGEN: Native IgM.
-
ایمونوفلورسانسآنتی بادی Human Kappa Light Chain (Polyclonal) -FITC
Anti-Human Kappa Light Chain
DESCRIPTION AND APPLICATIONS: Anti-Human Kappa Light Chain (Bound and Free)−FITC antibody is specific for human kappa light chain when tested against purified bound kappa light chain (human IgA, IgG, and IgM) and free kappa light chain (Bence Jones Kappa myeloma protein). The conjugate shows no reaction with bound or free lambda light chains. Mammalian antibodies contain one of two types of light chain, called kappa or lamba. Each chain contains a constant and a variable domain. Mammalian antibodies contain either two kappa or two lambda light chains.
This antibody should be used in conjunction with a panel of antibodies to aid in the identification of Kappa light chain of immunoglobulin in target tissue (e.g., in the diagnosis of renal or dermal pathologies). The interpretation of the results should be always corroborated with those of external controls and
COMPOSITION
Anti-human Goat Antibody to Kappa Light Chain. Fluorescein Conjugated Polyclonal antibody purified from serum and prepared in buffer with carrier protein and preservative for stabilization
IMMUNOGEN: Human kappa chains.
-
ایمونوفلورسانسآنتی بادی Human Lambda Light Chain (Mc24-IC6) -FITC
Anti-Human Lambda Light Chain
DESCRIPTION AND APPLICATIONS:
All five immunoglobulin classes share the same basic four polypeptide chain structure of two heavy-chains and two light chains. There are five heavy chain types, and two light-chain types (Kappa and Lambda) both having a molecular weight of 22.5kDa. Any heavy-chain type can associate with either light-chain type, but on any immunoglobulin molecule both light-chains are of the same type. Kappa and Lambda consist of a variable region and a constant region and can easily be differentiated by the antigenic properties of the constant region. The ratio of Kappa to Lambda is 70:30 , the vast majority of which is bound to heavy-chain in immunoglobulin. In normal individuals low levels of free light-chain arepresent in serum (kappa, 1.6-15.2 mg/L; Lambda, 0.4-4.2mg/L), with the occurrence of multiple myeloma or other B-cell malignancies these levels can be greatly elevated and can be found at high levels in the urine (Bence-Jones proteins).
COMPOSITION
Anti-human Mouse Antibody to Lambda Light Chain. Fluorescein Conjugated Monoclonal antibody purified from serum and prepared in buffer with carrier protein and preservative for stabilization.
IMMUNOGEN: Purified human IgG.