DESCRIPTION AND APPLICATIONS: The complement factor C3 consists of an alpha and a beta chain. C3 is a central factor in the complement cascade. It is central to the alternative pathway that leads to the C3 convertase C3bBb. The classical mannose binding lectin activation pathway leads to the C3 convertase C4b2a. These convertases cleave C3 resulting in C3a and C3b. Further degradation leads to the formation of the alpha chain products C3d, C3g and C3c. C3 is an acute phase protein that is produced by a wide range of tissues, including renal epithelial cells and hepatocytes. This antibody should be used in conjunction with a panel of antibodies to aid in the identification of C3c in target tissue (e.g., in the diagnosis of renal or dermal pathologies). The interpretation of the results should be always corroborated with those of external controls and integrated with the morphological and clinical aspects for the final diagnosis
COMPOSITION Anti-human Sheep Antibody to C3c. Fluorescein Conjugated Polyclonal antibody purified from serum and prepared in buffer with carrier protein and preservative for stabilization.
IMMUNOGEN: Human C3c purified from plasma