دسته: مونوکلونال

Specification:

The progesterone receptor (PgR) is an estrogen regulated protein. It has been proposed that expression of PgR determination indicates a responsive estrogen receptor (ER) pathway, and therefore, may predict likely response to endocrine therapy in human breast cancer. A number of studies have shown that PgR determination provides supplementary information to ER, both in predicting response to endocrine therapy and estimating survival. PgR has proved superior to ER as a prognostic indicator in some studies.

Immunogen:

Recombinant protein encoding human progesterone receptor 412-526 aa

Presentation:

Tissue culture supernatant with 0.2% BSA and 15mM sodium azide

Specification:

The catenin’s alpha, beta, and gamma are proteins which bind to the highly conserved, intracellular cytoplasmic tail of Ecadherin. Together, the catenin/cadherin complexes play an important role mediating cellular adhesion. Catenin, a 102 kDaprotein, was initially described as an E-cadherin-associated protein and has been shown to associate with other members of the cadherin family N-cadherin and P-cadherin. The 92 kDa catenin associates with the cytoplasmic portion  of E-cadherin which is necessary for the function of E-cadherin as an adhesion molecule. Catenin has also been found in complexes with the tumor suppressor protein APC. Catenin, also known as plakoglobin, is an 82 kDa protein that binds with catenin and Ncadherin. A related protein, p120, exhibits sequence homology with the catenins at four discreet domains. p120 not only serves as a substrate for Src but is also found in E-cadherin complexes containing catenins. p120 (15D2): sc-23872. Immunoperoxidase staining of formalin fixed, paraffin-embedded human breast tissue showing membrane and cytoplasmic localization.

Presentation:

Each vial contains 200 µg IgG in 1.0 ml of PBS with < 0.1% sodium azide 1 and 0.1% gelatin

Specification:

The LIM-only (LMO) proteins, LMO1 and LMO2, are nuclear factors that are characterized by a conserved LIM domain. The LIM domain consists of a cysteine-rich zinc-binding motif that is present in a variety of transcription factors, including the LIM homeobox (LHX) proteins expressed in the central nervous system and involved in cell differentiation. LMO1 and LMO2 are expressed in the adult CNS in a cell type-specific manner, where they are differentially regulated by neuronal activity and are involved in regulating the cellular differentiated phenotype of neurons. LMO2 lacks a specific DNA-binding homeobox domain but rather assembles into transcriptional regulatory complexes to mediate gene expression by interacting with the widely expressed nuclear LIM interactor (NLI). NLI, known also as CLIM-1, and the related protein CLIM2 facilitate the formation of heteromeric LIM complexes and also enhance the nuclear retention of LIM proteins. LMO2 and the related protein LMO4 are expressed in thymic precursor cells. LMO4 is also expressed in mature T cells, cranial neural crest cells, somite, dorsal limb bud mesenchyme, motor neurons, and Schwann cell progenitors.

Immunogen:

Recombinant LMO2 of human origin

Presentation:

Each vial contains 200 µg IgG1 in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Specification:

Reacts with a 70kDa membrane-bound isozyme of Placental Alkaline Phosphatase (PLAP) occurring in the placenta during the 3rd trimester of gestation. It is highly specific for PLAP and shows no cross reaction with other isozymes of alkaline phosphatase. Anti-PLAP reacts with germ cell tumors and can discriminate between these and other neoplasms. Somatic neoplasms e.g. breast, gastrointestinal, prostatic and urinary cancers may also immunoreact with antibodies to PLAP. Anti PLAP positive in conjunction with anti-keratin positive, but they regularly fail to stain with anti-EMA, whereas most carcinomas stain with anti-EMA. Anti-PLAP as been useful in the diagnosis of gestational trophoblastic disease.

Presentation:

Bioreactor Concentrate with 0.05% Azide

Specification:

Anti-EMA antibody is a useful marker for staining many carcinomas. It stains normal and neoplastic cells from various tissues, including mammary epithelium, sweat glands and squamous epithelium. Hepatocellular carcinoma, adrenal carcinoma and embryonal carcinomas are consistently EMA negative, so keratin positivity with negative EMA favors one of these tumors. EMA is frequently positive in meningioma, which can be useful when distinguishing it from other intracranial neoplasms, e.g. Schwannomas. The absence of EMA can also be of value since negative EMA staining is characteristic of some tumors including adrenal carcinoma, seminomas, paraganglioma and hepatoma.

Immunogen:

Delipidated extract of human milk fat globule membranes

Presentation:

Bioreactor Concentrate with 0.05% Azide

Specification:

CD21 antigen is an integral membrane glycoprotein of molecular weight 140 kD. Anti-CD21 is useful in the identification of follicular dendritic cell matrix found in normal lymph nodes and tonsillar tissue. This antibody also labels follicular dendritic cell tumor/sarcomas. The antigen is absent on T-lymphocytes, monocytes, and granulocytes. Associated products: CD35, Follicular Dendritic Cell

Presentation:

Anti-CD21 is a rabbit monoclonal from tissue culture supernatant diluted in tris buffered saline, pH 7.3-7.7, with protein base, and preserved with sodium azide