Name: CD57 Antibody Clone NK1
Description and applications: CD57 is expressed on a subpopulation of 15-20% of peripheral blood mononuclear cells, about 60% of NK active cells and on a subset of T cells. It also reacts with a variety of cell types in non-lymphoid tissues. Staining was observed in glandular epithelium of prostate, peripheral nerve and central nervous system, glandular epithelium of ovary, bronchiolar epithelium and in syncytiotrophoblasts. Variable staining was seen in the colloid of thyroid and some focal staining in kidney epithelium. Additionally, some staining was observed in capillaries of various tissues, subsets of pancreatic islet cells, hepatocytes and ovarian stromal cells. It stains neuroendocrine cells and their tumors. Identification of natural killer cells (NK) in tissue sections or cell suspensions together with other lymphoid markers may be useful in identifying indolent lymphoproliferative disorders of NK cells (CD57 +), leukemias large granular T cells (CD57 is expressed in the common variant), NK / T extranodal lymphoma (usually CD56 + / CD57-) and Hodgkin lymphoma nodular lymphocyte-predominant (nodular paragranuloma) which contains an abundant reactive population of cells that frequently surrounds the tumour cells (rosette-like). Additional staining was observed in a range of common tumours including colon adenocarcinoma, prostatic adenocarcinoma and ovarian carcinoma.
Composition: anti-human CD57 mouse monoclonal antibody purified from ascites and prepared in 10mM PBS, pH 7.4, with 0.2% BSA and 0.09% sodium azide.
Immunogen: Human peripheral blood mononuclear cells.