Name: CNPase Monoclonal Antibody clone 11-5B
Description and aplications: This monoclonal antibody recognises two proteins with a molecular mass of 46 kD (CNP1) and 48 kD (CNP2), identified as CNPase isoforms. CNPase (2’,3’-cyclic nucleotide 3′-phosphodiesterase) is expressed at high levels in oligodendrocytes of the central nervous system and in Schwann cells of the peripheral nervous system and it is virtually absent in other cell types. Since CNPase is expressed early in postnatal development, this antibody is useful for the identification of oligodendrocytes and Schwann cells. CNPase activity is decreased in demyelinating diseases such as multiple sclerosis. The CNPase gene is located on chromosome 17q21, very close to the familial breast cancer gene BRCA1. This antibody shows cross-reactivity with monkey, cow, sheep, goat, pig, cat, dog, rabbit, rat, and mouse. It does not cross-react with guinea pig and chicken.
Composition: Anti-human CNPase mouse monoclonal antibody purified from serum and prepared in 10mM PBS, pH 7.4, with 0.2% BSA and 0.09% sodium azide
Intended use: Immunohistochemistry (IHC) on paraffin embedded tissues. Not tested on frozen tissues or Western-Blotting