Name: Cytokeratin 5 Antibody Clone SP27
Description and applications:Twenty human keratins are divided into acidic (pI <5.7) and basic (pI >6.0) subfamilies. Members of the acidic and basic subfamilies are found together in pairs. The composition of keratin pairs varies with the epithelial cell type, stage of differentiation, cellular growth environment, and disease state. Many studies have shown the usefulness of keratins as markers in
cancer research and tumor identification. Point mutations in keratin 5 gene can cause various types of epidermolysis bullosa simplex. Keratin 5 is expressed in most epithelial cells, prostate basal cells and epithelial and biphasic mesotheliomas.
Composition: Anti-human Cytokeratin 5 rabbit monoclonal antibody purified from serum and prepared in 10mM PBS, pH 7.4, with 0.2% BSA and 0.09% sodium azide.
Immunogen: Synthetic peptide from Cterminus of human cytokeratin 5.