پروب فیش CDKN2A/CCP9 FISH Probe

INTRODUCTION: CDKN2A, also known as cyclin-dependent kinase Inhibitor 2A, is a gene which in humans is located at chromosome 9, band p21.3. It is ubiquitously expressed in many tissues and cell types. The gene codes for two proteins, including the INK4 family members, p16 (or p16INK4a) and p14arf. Both act as tumor suppressors by regulating the cell cycle. Abnormalities in CDKN2A – also known as ARF, MLM, P14, P16, P19, CMM2, INK4, MTS1, TP16, CDK4I, CDKN2, INK4A, MTS-1, P14ARF, P19ARF, P16INK4, P16INK4A or P16-INK4A – occur in gliomas and meningioma’s as well as numerous other familial and sporadic tumor types.
INTENDED USE: The CDKN2A/CCP9 FISH Probe Kit is designed to detect the human CDKN2A gene located on chromosome band 9p21.3, along with the number of chromosome 9 copies per cell and measure the copy number of the human CDKN2A gene located on chromosome band 9p21.3.

PROBE DESCRIPTION: The CDKN2A Probe of the CDKN2A/CCP9 FISH Probe kit labeled with the fluorochrome CytoOrange covers a chromosomal region which includes the entire CDKN2A gene. The CCP9 Probe of the CDKN2A/CCP9 FISH Probe kit labeled with the flourochrome CytoGreen is derived from chromosome 9-specific alpha satellite DNA is designed to serve as a control to determine the number of chromosome 9 copies per cell.