Name: Fli-1 Antibody-Clone MRQ-1
Description and applications: The FLI-1 gene encodes the transcription factor of the same name (FLI-1 “Friend leukemia integration 1 transcription factor”) that has a fundamental role in embryonic development of blood vessels. Expression of Fli-1 appears as the first reliable marker of endothelial differentiation. In tumors such as Ewing sarcoma / primitive neuroectodermal tumor (ES / PNET), FLI-1 plays a pathogenic role and more than 90% of ES / PNET have the translocation t (11; 22) (q24, q12) producing the EWS fusion gene located on chromosome 22 with the Fli-1 gene located on chromosome 11. In other tumors, nuclear positivity for FLI-1 has been detected in 95% of benign (hemangiomas) and malignant (hemangioendothelioma, angiosarcoma, Kaposi’s sarcomas) vascular tumors, in different lymphomas, including lymphomas of precursor cells (lymphoblastic leukemia / lymphoblastic lymphoma), T cell lymphoma, of anaplastic large cell lymphomas, T angioinmmunoblastic lymphoma, enteropathy-associated T-cell lymphoma, all stages of mycosis fungoides with variable intensity and in 50% of peripheral T-cell lymphoma NOS. It was recently reported in melanomas.
Composition: anti-Fli1 mouse monoclonal antibody obtained from supernatant culture and prediluted in a tris buffered solution pH 7.4 containing 0.375mM sodium azide solution as bacteriostatic and bactericidal.