آنتی­ بادی MUM1/IRF4 (MUM1p)

Name: MUM1 Antibody (Clone MUM1p)

Description and aplications: MUM1 / IRF4 is an oncogene associated with myeloma. The protein has a molecular weight of 51.6 kDa and is encoded by a gene on chromosome 6p25-p23 region located mainly in the nucleus of lymphocytes. When MUM1 is not expressed, the B / T cells do not get activated and the immunoglobulins are not secreted by the plasma cells. Most neoplasms composed of mature lymphoid cells express MUM1. Therefore, this protein is expressed in a subset of B cells in the germinal center in plasma cells and in activated T cells. MUM1 is a marker that helps in characterizing the histogenesis of lymphoma / leukemia of B origin. In Bcell lymphomas, MUM1 expression presents a predictive role of the genetic profile and represents, together with CD10 and BCL-6, the base of Hans classification for diffused large B cell lymphomas. MUM1 positivity, in these cases, suggests a non-germinal center phenotype and is predictive for prognosis, especially in pediatric cases. In Burkitt lymphomas, that shares cytological, architectural and histological aspects with some cases of DLBCL of “Burkitt-like”, the MUM1 is negative in general or positive in a small percentage of cases or tumoral cells. All cases of primary effusion lymphomas and most cases of primary brain lymphomas are MUM1 positive. Other lymphoid neoplasm express MUM1. Melanomas can also stain with MUM1.

Composition: anti-MUM1 mouse monoclonal antibody obtained from supernatant culture and prediluted in a tris buffered solution pH 7.4 containing 0.375mM sodium azide solution as bacteriostatic and bactericidal.